Active Cancer Brain & Nervous System

Minimising side effects of Anaplastic Lymphoma Kinase (ALK) inhibitors for neuroblastoma by elimination of off-target activity

About this grant

This summary is based on the grant title only — the full abstract was not available.

Research project funded by MRF at Institute of Cancer Research.

View the original record at the funder ↗

Researchers

Elizabeth Tucker (EPMC Awardee)

Related Research

Grants with similar aims, by meaning.

Therapeutic Targeting of ALK in Neuroblastoma
Targeting the ALK-F1174L tyrosine-kinase mutation in treatment refractory neuroblastoma.
An investigation into the treatment of neuroblastoma with mutations of Anaplastic Lymphoma Kinase (ALK), using LDK378 and LEE011 combination therapy targeting ALK and Cyclin-dependent Kinase (CDK) 4/6, in a preclinical transgenic neuroblastoma model
Phase I study of Lorlatinib (PF-06463922), an oral small molecule inhibitor of ALK/ROS1, for patients with ALK-driven relapsed or refractory neuroblastoma
Improved Treatment of Childhood Neuroblastoma - Targeting the Oncogene Drivers MYCN and ALK, and Identification of Therapy Resistance Mechanisms

Original classification

Impact of Cancer and Cancer Care on Human Biology and Health 2025

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