Completed Cancer Public Health & Healthcare

The yorkshire lung screening trial

In plain English

AI plain-English summary

A mobile lung cancer screening unit will park in Leeds supermarket car parks and community centres, offering CT scans to people at high risk of the disease. The Yorkshire Lung Screening Trial is designed to solve a practical problem: a large US trial showed that low-dose CT screening cuts lung cancer deaths by 20%, but the UK has not yet implemented a national programme. Key obstacles remain unclear—specifically, which groups of high-risk people should be invited to maximise both effectiveness and value for money, and how to make screening easier to access so more people actually take part. The trial will test three different strategies for identifying high-risk individuals, comparing them head-to-head for the first time. If successful, the findings could reshape how the NHS delivers lung cancer screening, shifting it from hospital-based appointments to mobile units in local communities. That could mean earlier diagnosis for thousands of people who currently miss out, and a measurable reduction in lung cancer deaths across the population.

View original technical description
Screening high-risk patients with low-dose computed tomography (LDCT) reduced lung cancer mortality by 20% in a large US trial. Unresolved issues for UK implementation include clarification of which high-risk group should be invited for screening to maximise efficacy and cost-effectiveness, and how to improve participation by reducing barriers to screening. The Yorkshire Lung Screening Trial will evaluate a community-based screening programme in mobile units across Leeds through a Zelen’s design study, allowing assessment of the overall effect of screening across the population. Three proposed strategies to identify high risk patients for screening will be prospectively compared for the first time.

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Researchers

Matthew Callister (EPMC Awardee)

Related Research

Grants with similar aims, by meaning.

Yorkshire Lung Screening trial
Yorkshire Lung Screening trial: biomarker study
Yorkshire Lung Screening Trial: Biomarker Sub-study
Yorkshire Kidney Screening Trial (YKST) - a Yorkshire Lung Screening Trial Sub-study
United Kingdom Lung Cancer Screening Trial (UKLS) - Pilot

Original classification

Research Grant

Plain English summaries and category classifications on this site are generated by AI and may not perfectly reflect the original research.