Active Heart, Stroke & Blood NIHR-supported project Brain & Nervous System

AVEIR Leadless Pacemaker (LP) UK Registry

In plain English

AI plain-English summary

A new generation of pacemakers—small enough to be implanted directly into the heart without wires—is being tracked in a UK-wide registry of 300 patients across 15 hospitals over five years. Why this matters: Standard pacemakers require leads (wires) that run from a chest pocket device to the heart. These leads can break, become infected, or dislodge. Leadless pacemakers, like the AVEIR device, eliminate those risks by sitting entirely inside the heart. But because the AVEIR is the newest approved model, its real-world performance—both during the implant procedure and over years of use—is not yet well documented. The registry collects data on which patients receive it, why clinicians choose it, and how safe and effective it proves in everyday NHS practice. Potential impact: If the registry shows the AVEIR pacemaker is as safe and effective as earlier models, it could become a standard option for patients who need pacing but face higher risks from traditional lead-based devices. This would directly improve care for people with heart conditions that slow or block the heart’s electrical signals, reducing complications and hospital readmissions. The findings will also help NHS hospitals decide which patients benefit most from this technology, shaping procurement and clinical guidelines for years to come.

View original technical description
AVEIR LP UK Registry is a study collecting data from patients who need to have a leadless pacemaker inserted due to underlying heart diseases. Leadless pacemaker technology promises to revolutionise care of the patients that require pacing. The AVEIR pacemaker is the newest of approved leadless pacemakers. Vigilant surveillance of its use in real clinical practice with respect to the effectiveness and safety of the device, at the time of the procedure as well as in the long-term, is essential to ensure that patients receive the best care. The focus is on the data related to the characteristics of the patients that need this type of pacemaker, the reasons why the pacemaker was chosen by their clinical care teams, the safety and efficacy of the device. We plan to recruit and consent 300 patients from up to 15 hospitals over 24 months and follow them up for 5 years.The study is funded by Abbott Ltd and is Sponsored by the Royal Brompton and Harefield Hospitals, part of the Guy’s and St Thomas’ NHS Foundation Trust.

Researchers

Tom Wong (Principal Investigator)

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