Recipient organisationNIHR Cambridge Biomedical Research Centre
NIHR supportRecorded as supported by this research centre
PeriodMar 2025 — Dec 2025
In plain English
AI plain-English summary
A new type of light-based brain monitor is being tested on severely head-injured patients in a Cambridge intensive care unit, without requiring any surgery or skin penetration. Severe traumatic brain injury (TBI) can trigger dangerous secondary complications—such as swelling or reduced blood flow—that are difficult to detect early with current bedside tools. Existing monitors often require invasive probes or provide limited information. This study evaluates two improved near-infrared spectroscopy (NIRS) devices that shine light through the skull to measure brain activity and blood flow continuously. By monitoring up to 50 adults over daily six-hour sessions for up to two weeks, researchers aim to determine whether these non-invasive devices can reliably flag complications in real time. If successful, the devices could give neurocritical care teams a safer, simpler way to track brain health after severe injury, potentially reducing the need for invasive monitoring and enabling earlier interventions. This would not change daily life for most people, but it could quietly improve survival and recovery outcomes for the thousands of patients who suffer severe TBIs each year—without adding risk or discomfort to their care.
View original technical description
This project seeks to evaluate the capabilities of new Near Infrared Spectroscopy (NIRS) devices, which use light to measure brain activity, for monitoring how the brain and body react after a serious head injury (TBI), particularly in the immediate and shortly following periods. Data recorded from these devices will help determine if they can effectively monitor additional complications and outcomes in adults over 18 with severe TBIs in a specialised intensive care unit for brain injuries (NCCU) at Addenbrooke's Hospital (Cambridge, UK). We will use two different NIRS devices similar to those currently used in the NCCU but with extra improvements. Both devices are proven to be safe and do not require surgery or internal procedures. Participants will be recruited based on several criteria and monitored early in their NCCU admission. Monitoring will be daily for 6 hours, lasting from half a week to two weeks, depending on recovery progress. After the initial 10 patients, we will perform an interim analysis and may adjust the recording duration. We aim to recruit a maximum of 50 participants in total. Due to their condition, participants will not be able to give permission to participate, so we will seek it from their next of kin within 24 hours of admission. The study will only observe and not influence treatment. We will also collect additional clinical data, such as scans, the patient's condition six months after the injury, and other medical information for analysis. The data collection period for this study will last up to 2 years. We will remove any personal details from the patient data. The body function data, with personal details removed, will be transferred and stored on the Brain Physics Lab server (segregated) and University of Cambridge computers for analysis. Any data not saved in dedicated long-term storage will be deleted after use.
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