Completed Digestion, Kidneys & Other Organs NIHR-supported project Pregnancy, Children & Inherited Conditions

Paediatric ONS Blends Acceptability (including gastrointestinal tolerance, compliance and palatability) of a paediatric oral nutritional supplement containing food blends.

In plain English

AI plain-English summary

Children who rely on tube feeding often suffer gut discomfort, bloating, or vomiting from standard liquid formulas, and this study tests whether a new blend of real food—developed by Nestlé Health Science—is easier for them to tolerate. The problem is that many children with conditions like short bowel syndrome, inflammatory bowel disease, or feeding intolerances cannot eat normally and depend on liquid nutrition through a tube. Homemade blended diets are sometimes used instead, but they carry risks of contamination or inconsistent nutrition. No commercial food-blend product has been rigorously tested in children for how well the gut handles it, how much children will actually drink, and whether they find it palatable. This single-arm study will enroll 25 children who already require tube feeding. Over 28 days, they will receive the food-blend formula alongside or instead of their usual feed. Parents will keep daily diaries and complete questionnaires on symptoms, intake, and tolerance. Recruitment runs for 12 months. If the blend proves well-tolerated and acceptable, it could give clinicians a safer, standardised alternative to homemade blends—reducing gut symptoms and improving nutritional intake for a vulnerable group of children who currently have limited options.

View original technical description
Gastrointestinal tolerance describes the ability of the digestive system, including the stomach, small intestine and large intestine to function smoothly, accept and process food comfortably and absorb nutrients from food or formula without causing discomfort or adverse reactions. There are several factors that can affect the tolerance of the digestive system. These include structural abnormalities or malabsorption issues, caused by any of the following conditions: short bowel syndrome? intractable malabsorption? preoperative preparation of undernourished patients? inflammatory bowel disease? total gastrectomy? dysphagia? bowel fistulae? feeding intolerances, developmental disabilities and disease related malnutrition. Patients with gastrointestinal tolerance problems require nutritional support strategies such as bolus tubes feed. This is because they can significantly impact an individual’s ability to consume adequate nutrition. This study is a single arm, prospective, multi-centre study that will include twenty five(25) participants (children only) who require oral tube feed with food blend for their dietary management. Compleat blends that were developed by Nestle Health Science will be used. The study will evaluate the gastrointestinal tolerance and compliance of the oral tube feed over a period of 28 days. Participants will receive oral tube feed alongside or instead of their usual feed or home-made blended diet. Participants will be asked to complete a daily diary and a short questionnaire to record information. The recruitment period will be 12 months.

Researchers

Sarah Durnan (Principal Investigator)

Related Research

Grants with similar aims, by meaning.

Acceptability (including gastrointestinal tolerance, compliance and palatability) of a paediatric oral nutritional supplement containing food blends.
Tolerance, compliance and acceptability to a new nutritional feed comprising real food ingredients
Blended diet for tube administration in neurologically impaired children
Acceptability (including gastrointestinal tolerance and compliance) of a plant based high energy adult enteral formula
The role of different diets in children who are gastrostomy fed

Original classification

Gastrointestinal and Liver Disorders

Plain English summaries and category classifications on this site are generated by AI and may not perfectly reflect the original research.