CompletedDigestion, Kidneys & Other OrgansNIHR-supported projectPregnancy, Children & Inherited Conditions
Paediatric ONS Blends Acceptability (including gastrointestinal tolerance, compliance and palatability) of a paediatric oral nutritional supplement containing food blends.
NIHR supportRecorded as supported by this research centre
PeriodMar 2025 — Oct 2025
In plain English
AI plain-English summary
Children who rely on tube feeding often suffer gut discomfort, bloating, or vomiting from standard liquid formulas, and this study tests whether a new blend of real food—developed by Nestlé Health Science—is easier for them to tolerate. The problem is that many children with conditions like short bowel syndrome, inflammatory bowel disease, or feeding intolerances cannot eat normally and depend on liquid nutrition through a tube. Homemade blended diets are sometimes used instead, but they carry risks of contamination or inconsistent nutrition. No commercial food-blend product has been rigorously tested in children for how well the gut handles it, how much children will actually drink, and whether they find it palatable. This single-arm study will enroll 25 children who already require tube feeding. Over 28 days, they will receive the food-blend formula alongside or instead of their usual feed. Parents will keep daily diaries and complete questionnaires on symptoms, intake, and tolerance. Recruitment runs for 12 months. If the blend proves well-tolerated and acceptable, it could give clinicians a safer, standardised alternative to homemade blends—reducing gut symptoms and improving nutritional intake for a vulnerable group of children who currently have limited options.
View original technical description
Gastrointestinal tolerance describes the ability of the digestive system, including the stomach, small intestine and large intestine to function smoothly, accept and process food comfortably and absorb nutrients from food or formula without causing discomfort or adverse reactions. There are several factors that can affect the tolerance of the digestive system. These include structural abnormalities or malabsorption issues, caused by any of the following conditions: short bowel syndrome? intractable malabsorption? preoperative preparation of undernourished patients? inflammatory bowel disease? total gastrectomy? dysphagia? bowel fistulae? feeding intolerances, developmental disabilities and disease related malnutrition. Patients with gastrointestinal tolerance problems require nutritional support strategies such as bolus tubes feed. This is because they can significantly impact an individual’s ability to consume adequate nutrition. This study is a single arm, prospective, multi-centre study that will include twenty five(25) participants (children only) who require oral tube feed with food blend for their dietary management. Compleat blends that were developed by Nestle Health Science will be used. The study will evaluate the gastrointestinal tolerance and compliance of the oral tube feed over a period of 28 days. Participants will receive oral tube feed alongside or instead of their usual feed or home-made blended diet. Participants will be asked to complete a daily diary and a short questionnaire to record information. The recruitment period will be 12 months.
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