Completed Bones, Joints & Muscles NIHR-supported project Cancer

Body Composition in Older Adults with Cancer

In plain English

AI plain-English summary

A bioelectrical impedance machine will measure the fat, muscle, and water content of older adults with cancer as they undergo chemotherapy. People aged 70 and over are both the fastest-growing group of cancer patients and the most underrepresented in research. Clinicians currently lack clear evidence on how body composition—specifically the loss of muscle and fat known as cachexia and sarcopenia—changes during treatment, or whether those changes differ by tumour type. Without this knowledge, nutritional support remains generic rather than tailored. This study will track those changes alongside simple physical measures such as handgrip strength and calf circumference, then analyse the data for trends. If successful, the work will provide the descriptive foundation needed to design personalised nutritional care for older cancer patients. That could mean adjusting diet or supplements to preserve muscle mass during treatment, potentially improving tolerance to chemotherapy and quality of life. Because the study is descriptive and exploratory, it will not produce immediate clinical guidelines, but it will identify which patterns and associations warrant larger, definitive trials in a population that is routinely excluded from cancer research.

View original technical description
The primary aim of the study is to explore body composition (the fat, muscle and water content of someone's body) in older adults (aged 70 years and over) with cancer, undergoing systemic anticancer treatment (e.g., chemotherapy). Additional aims include to explore the extent of body composition changes and whether changes are tumour specific, the incidence for cancer-related cachexia and sarcopenia (muscle +/- fat wasting conditions) and finally, how body composition can inform nutritional management of older adults with cancer. Measurements will include an analysis from the Bioelectrical Impedance Analysis (BIA) machine which measures the fat, lean muscle, and water content in the body? waist to hip ratio? handgrip strength? calf circumferences. Socio-demographic data (such as age, cancer diagnosis) will also be collected. I intend to descriptively analyse this data to explore possible trends and associations which may inform future research and drive even further personalised care for this growing and typically underrepresented in research, population.

Researchers

Megan Pattwell (Principal Investigator)

Related Research

Grants with similar aims, by meaning.

CANDO-1: A cohort study to investigate body composition in women with breast cancer
A cohort study to investigate body composition in women with breast cancer
Body composition measurement and its prognostic value in aging and disease
CANDO-3: Body composition and chemotherapy toxicity in women with early breast cancer
Understanding factors that influence breast cancer risk, disease progression and treatment outcomes

Original classification

Cancer Treatment Effects

Plain English summaries and category classifications on this site are generated by AI and may not perfectly reflect the original research.