Completed Lungs & Breathing NIHR-supported project Mental Health

Living BetteR with asThma studY (Nutrition)

In plain English

AI plain-English summary

People with difficult-to-treat asthma are being offered a six-month programme of personalised exercise, mental wellbeing support, breathing retraining, and dietary advice to see if tackling multiple health problems at once can improve their symptoms. This matters because difficult-to-treat asthma rarely travels alone. Most patients also struggle with conditions like obesity, anxiety, or disordered breathing patterns, yet standard care typically treats the lungs in isolation. The researchers have already shown that a targeted exercise intervention alone can reduce inflammation and improve symptoms. Now they want to test whether a broader, patient-designed package of behaviour changes works better than exercise alone. If the pilot succeeds, it will provide the evidence needed to launch larger trials across the NHS. That could shift how asthma clinics operate—moving from single-disease management to integrated care that addresses the whole person. For patients, this might mean fewer flare-ups, less reliance on rescue inhalers, and a genuinely better quality of life. For the health service, it could reduce hospital admissions and long-term treatment costs. The funding will add a second hospital site and dedicated dietitian time, testing whether the approach works outside a single specialist centre.

View original technical description
Our research focuses on multimorbidity in difficult-to-treat asthma (DA). We have demonstrated the nature of multimorbidity and detrimental impact of comorbidities like psychological comorbidity, breathing pattern disorder and obesity in DA. Furthermore, our preliminary data demonstrate that a targeted exercise intervention improves symptoms, inflammation and oxidative stress buffering in DA. We therefore hypothesise that multimodal behaviour change interventions will improve clinical outcomes in DA patients. We will test that in a BMA James Trust-funded pilot study within our Wessex-wide DA clinical service. In this LIving BEtteR with AsThma studY (LIBERTY), we have co-developed with patients a multimodal behaviour change intervention for DA. This study comprises a structured 6-month personalised exercise programme, mental wellbeing guidance, breathing pattern retraining and dietary advice that subsequently becomes patient-led. Clinical outcomes will be assessed along with blood sampling to identify underlying mechanistic pathways. Findings will form the basis for future larger-scale studies. The WEMN funding will support widening of the LIBERTY to an extra site – Hampshire Hospitals NHS FT with costed dietitian time at that site.

Researchers

Anna-Maria Holt (Principal Investigator)

Related Research

Grants with similar aims, by meaning.

LIving BEtteR with asThma studY (LIBERTY-PS)
Living BetteR with Asthma – Intervention Development (LIBERTY-ID)
Investigating the feasibility of a mobile mindfulness-based digital intervention for patients with asthma
Breathing REtraining for people with AsTHma and breathing pattern disorder (BREATH)
Supported Self-Management for People with Type 2 Diabetes in Primary Care

Original classification

Respiratory and Allergy (RA)

Plain English summaries and category classifications on this site are generated by AI and may not perfectly reflect the original research.