Unknown Mental Health NIHR-supported project Diabetes, Hormones & Metabolism

Identifying adequacy of hyperprolactinemia assessment in patients on antipsychotics under a specific community mental health team in Southwark

In plain English

AI plain-English summary

Nearly half of people taking first-generation antipsychotics experience sexual dysfunction, yet doctors often fail to check for the underlying cause—a hormone imbalance called hyperprolactinemia. This matters because antipsychotics that block D2 receptors can raise prolactin levels, and as a 2002 study by Smith and colleagues showed, this effect likely overrides other causes of sexual dysfunction in these patients. The problem is that clinical assessments and blood tests for prolactin are frequently skipped, leaving a common and distressing side effect unaddressed. This project will scan electronic health records from a community mental health team in Southwark to determine how often clinicians actually assess for signs of hyperprolactinemia—both through symptom checks and lab monitoring. If the research reveals gaps in assessment, it could lead to simple changes in clinical practice: routine prolactin blood tests and structured questions about sexual side effects during patient reviews. That would not only improve quality of life for people on antipsychotics but also reduce the risk of long-term complications from untreated hyperprolactinemia, such as bone density loss. The work is a focused audit of current care, not a fundamental discovery—but its findings could directly reshape how a common, overlooked side effect is managed in mental health services.

View original technical description
The rationale for this project is the high prevalence of sexual dysfunction in people taking antipsychotics (Almost 45% of people on first generation antipsychotics had reported to suffer from sexual dysfunction in one study in 2002) - many antipsychotics with strong D2 receptor blocking action are known to increase the prolactin level which, as per Smith et al, 2002, is likely to override any other possible causes of sexual dysfunction in people on antipsychotics. This project aims at scanning the electronic records of patients under a specific Community Mental Health Team in Southwark borough, on antipsychotic(s), to assess if sexual side effects focusing on signs and symptoms of hyperprolactinemia are being clinically assessed during patient reviews, in addition to laboratory monitoring of serum prolactin.

Researchers

Sanchari Mukhopadhyay (Principal Investigator)

Related Research

Grants with similar aims, by meaning.

REMEDY: Randomised Evaluation of Management of sExual DYsfunction
Aripiprazole treatment for antipsychotic induced hyperprolactinaemia in young patients with severe mental illness and learning disabilities
The RESPECT Study (Randomised Evaluation of Sexual health Promotion Effectiveness informing Care and Treatment): a feasibility study of an intervention aimed at improving the Sexual Health of People with Severe Mental Illness
Improving Physical Health and Decreasing Cannabis Abuse in People With Severe Mental Illness
Long term outcomes and health inequalities in bipolar affective disorder within a UK primary care cohort (1995-2012)

Original classification

Informatics

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