Completed Heart, Stroke & Blood Pregnancy, Children & Inherited Conditions

The HAEM (Haemorrhage and Antifibrinolytics in Emergency Medicine – WOMAN TRIAL)

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AI plain-English summary

A cheap drug already proven to save bleeding accident victims is now being tested on women haemorrhaging after childbirth. Sudden severe bleeding is a major cause of death and disability worldwide, and postpartum haemorrhage is a leading killer of new mothers. The drug, tranexamic acid, has been used safely for decades in surgery to control bleeding, but its potential to treat a much wider range of bleeding emergencies has only recently become clear. The research team, who led the landmark trial in trauma patients, will now run a large international trial to see whether the same drug cuts deaths and improves recovery in women bleeding after giving birth. If it works, the impact would be immediate and global: tranexamic acid is cheap, stable, and already widely available, meaning it could be deployed in low-resource maternity wards and emergency rooms around the world with minimal training or infrastructure. This is not fundamental science—it is a direct test of a low-cost intervention against a common, lethal problem, with results that could change standard care for millions of women.

View original technical description
Sudden severe bleeding is an important medical problem in the UK and world-wide. Recent results from a large international clinical trial in bleeding accident victims show that a cheap drug called tranexamic acid reduces the chances of dying from the injuries and improves other patient outcomes without any increase in side effects. Tranexamic acid is not a new drug. It has been used to control bleeding during major surgical operations for many years. The realisation that this drug could be used to treat a much wider range of bleeding conditions holds the promise of important benefits for patients at low cost. The research team responsible for the accident victim research now want to conduct a trial to see if this drug improves outcome in post-partum bleeding. They are experienced in carrying out this sort of research and have an established network of doctors from all around the world that will be able to answer this important medical question.

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Related Research

Grants with similar aims, by meaning.

The HAEM (Haemorrhage and Antifibrinolytics in Emergency Medicine) Project.
The Women-2 Trial -Tranexamic acid for preventing postpartum haemorrhage
The CRASH-3 Trial: Tranexamic acid for the treatment of significant traumatic brain injury.
CRASH2 Trial, a large randomised placebo controlled trial among trauma patients with significant haemorrhage of the effects of an antifibrinolytic treatment on death and transfusion requirement
Intramuscular tranexamic acid for the treatment of symptomatic mild traumatic brain injury in older adults: a randomised, double-blind, placebo-controlled trial.

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