MyoGuide+: accelerating the diagnosis of patients with neuromuscular diseases applying artificial intelligence to muscle MRIs

Myo-Guide represents a cutting-edge tool exploiting the power of machine learning to accurately predict the diagnosis of up to 20 distinct neuromuscular diseases. This is achieved through the analysis of fatty replacement patterns in skeletal muscles, as assessed by muscle MRI. After years of dedicated development, Myo-Guide is now accessible free of charge through the web platform myoguide.org, with the primary objective of assisting healthcare providers in efficiently reaching diagnoses for patients. Our commitment to advancing medical diagnostics propels us to enhance Myo-Guide further. The ongoing efforts include broadening its predictive capabilities to encompass additional diseases expanding the anatomical coverage to include the trunk, upper limbs, and cranial muscles. Additionally, we seek to incorporate information regarding inflammatory changes within muscles, discernible through the utilization of Short Tau Inversion Recovery sequence. A pivotal aspect of this evolution involves the creation of an automatic segmentation tool, to identify and quantify fat replacement of muscles, with the aim to significantly facilitate the diagnostic workflow for clinicians using the system. Furthermore, we aim to refine the web interface housing the machine learning tool. The forthcoming updates encompass a more intuitive and user-friendly interface tailored specifically for clinicians. The introduction of a novel segmentation tool stands as a pivotal enhancement, complemented by the inclusion of an atlas detailing the patterns observable in patients with different diseases. Moreover, we am to incorporate educational resources, including videos and documents, to benefit clinicians, patients, their families, and the general public.