Completed Genetics & Molecular Biology Chemistry

DNA Synthesis at the Norwich Research Park

In plain English

AI plain-English summary

A new DNA synthesis facility at the Norwich Research Park will build custom genetic sequences to help scientists engineer plants and microbes that produce novel antibiotics, pigments, and other high-value compounds. The facility addresses a practical bottleneck. Researchers who discover a promising gene in a medicinal plant or soil bacterium often need to chemically synthesise that DNA to study it or insert it into a production organism. Without a local, dedicated facility, researchers rely on commercial suppliers, which can be slow and expensive. This centre will give scientists on-site control over the design and production of synthetic DNA, accelerating the cycle of discovery and testing. If the facility succeeds, it could speed up the development of new antibiotics to combat drug-resistant infections, and improve the manufacture of natural colourants and fragrances for the food and cosmetics industries. It will also support genome editing tools, allowing researchers to precisely modify plant and microbial genomes. Beyond immediate products, the facility will enable computational modelling of gene networks, placing it at the intersection of systems and synthetic biology. This is primarily a technology platform that enables other fundamental and applied research, rather than a project with a single practical endpoint.

View original technical description
We propose to set up a DNA Synthesis facility at the Norwich Research Park (NRP) with the aim to support the design, generation and exploitation of high-value compounds and bioactives obtained from plants and microbes. These are areas of strength within the Norwich Research Park (NRP) which hosts a number of research institutes with strategic programmes that are recognised as international leaders, in particular in areas around the generation of novel antibiotics and other valuable secondary metabolites such as terpenes and anthocyanins. More recently the development of targeted genome editing technologies have emerged as another complementary area of strength within the NRP. The DNA synthesis facility within the NRP will also contribute to enhance the opportunities to develop computational methods in areas relevant to systems biology complementing other technology platforms within the NRP. The focus will be on the modelling of gene networks, which is placed at the interface of systems and synthetic biology.

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Researchers

Daniel Swan (Principal Investigator)Mario Caccamo (Principal Investigator)

Related Research

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Bioreactor capability for the Plant and Microbe DNA Foundry
NREL Partnership: Engineering synthetic RNA devices to expediate the evolution of metabolite producing micro-organisms
Enzymatic gene synthesis
A DNA Synthesis and Construction Foundry for Synthetic Biology @ Imperial College

Original classification

Research Grant

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