Microbial communities living in hot springs will reveal how microbes turn CO₂ into useful chemicals, from biofuels to potential antibiotics. Most microbiomes—in soil, on skin, in the gut—are too complex to understand from scratch. This project sidesteps that complexity by studying low-diversity communities in geothermal springs, where fewer species interact. The goal is to uncover the fundamental “rules of life” that govern how microbes cooperate or compete to convert CO₂ into valuable products. Without these rules, scientists cannot reliably predict or control what a microbiome does, limiting efforts to engineer microbes for practical use. If successful, the research could transform waste CO₂ from a pollutant into a feedstock for manufacturing. The primary metabolites produced directly by microbial growth could become platform chemicals for industry or biofuels. Secondary metabolites, which often have antibiotic or anticancer properties, could yield new pharmaceuticals. The project also aims to build predictive models that infer microbiome function from genomic data alone—tools that could eventually help improve soil health, gut function, and other complex microbial systems. This is fundamental science. It seeks to understand how microbial communities work, not to deliver a commercial product tomorrow. But past discoveries of microbial rules have led to everything from gene editing to industrial fermentation.
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Microbial communities (often called microbiomes) are everywhere; on our skin, in our gut, in the soil we rely on to grow our food, indeed in almost every habitable environment on the planet. Members of microbiomes interact with one another in myriad ways which we are only just beginning to appreciate, thanks largely to powerful new tools at our disposal. In this ambitious, multidisciplinary project, we bring together expertise to use these tools to unearth the 'rules of life' that govern the interactions between microbial community members, with the view to develop predictive approaches that can help us to understand and control microbiome function. Drawing on low diversity communities that inhabit geothermal springs, we will interrogate the metabolic, ecological and evolutionary interactions between community members that collectively govern the conversion of CO2 into value-added products. These products span primary metabolites that result from direct microbial growth (and hold value as platform chemicals for manufacturing industries and as biofuels), as well as secondary metabolites that are not directly liked to growth but that play ill-defined roles in microbial communities, and often harbour bioactive properties of high value to society (e.g. antibiotics, anticancers). We will use synthetic biology approaches to engineer the microbiome and its metabolic pathways of interest, both as a learning tool with which to test hypotheses on metabolite production and function, and as a means to augment the CO2 bioconversion capacity of the system for future biotechnological development. In parallel, we will apply ecological and metabolic modelling approaches to continue to generate hypotheses that can be tested with our model system, and which will be integrated into new predictive tools to accurately infer function from microbiome genomic data. Crucially, these approaches will work in tandem to help resolve the microbe-microbe interactions that drive this model system, which we have deliberately chosen to maximise the success of our ambitious goals. By unravelling the rules of life in these low-diversity systems, we will take the first major step towards understanding the more complex communities that impact our ability to grow food and live healthy lives. At the same time, our project promises to deliver new ways to turn waste CO2 emissions into waste, towards a more sustainable and Net Zero future.
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