Active Chemistry Materials & Manufacturing

SynHiSel

In plain English

AI plain-English summary

Chemical separations—from purifying medicines to cleaning water—consume 10–15% of the world's total energy. SynHiSel aims to slash that by creating membranes that are far more selective, targeting a tenfold improvement in energy efficiency. This matters because current separation processes are wasteful and costly. The US Department of Energy estimates that better membranes could save 100 million tonnes of CO₂ emissions and £3.5 billion in energy costs annually. In healthcare, they could separate active from inactive viruses, lowering the cost of biologic drugs. In water treatment, they could remove micropollutants at trace concentrations. For chemical manufacturing, they could strip out potent inhibitors during feedstock preparation, boosting productivity. If successful, SynHiSel would not just tweak existing processes—it would enable entirely new high-value, low-carbon manufacturing routes. The project focuses squarely on selectivity, while maintaining gains already made in permeance and longevity. The result could be a step-change in how the global community designs separation processes, with direct benefits for UK industry, clean growth, and resource efficiency.

View original technical description
Chemical separations are critical to almost every aspect of our daily lives, from the energy we use to the medications we take, but consume 10-15% of the total energy used in the world. It has been estimated that highly selective membranes could make these separations 10-times more energy efficient and save 100 million tonnes/year of carbon dioxide emissions and £3.5 billion in energy costs annually (US DoE). More selective separation processes are essential to "maximise the advantages for UK industry from the global shift to clean growth", and will assist the move towards "low carbon technologies and the efficient use of resources" (HM Govt Clean Growth Strategy, 2017). In the healthcare sector there is growing concern over the cost of the latest pharmaceuticals, which are often biologicals, with an unmet need for highly selective separation of product-related impurities such as active from inactive viruses (HM Govt Industrial Strategy 2017). In the water sector, the challenges lie in the removal of ions and small molecules at very low concentrations, so-called micropollutants (Cave Review, 2008). Those developing sustainable approaches to chemicals manufacture require novel separation approaches to remove small amounts of potent inhibitors during feedstock preparation. Manufacturers of high-value products would benefit from higher recovery offered by more selective membranes. In all these instances, higher selectivity separation processes will provide a step-change in productivity, a critical need for the UK economy, as highlighted in the UK Government's Industrial Strategy and by our industrial partners. SynHiSel's vision is to create the high selectivity membranes needed to enable the adoption of a novel generation of emerging high-value/high-efficiency processes. Our ambition is to change the way the global community perceives performance, with a primary focus on improved selectivity and its process benefits - while maintaining gains already made in permeance and longevity.

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Researchers

Andrew Livingston (Co-Investigator)Davide Mattia (Principal Investigator)Greg Mutch (Co-Investigator)Ian Metcalfe (Co-Investigator)Kang Li (Co-Investigator)Maria Perez-Page (Co-Investigator)Maria-Chiara Ferrari (Co-Investigator)Neil McKeown (Co-Investigator)Peter Budd (Co-Investigator)Qilei Song (Co-Investigator)Shiqi Huang (Co-Investigator)Yong Chew (Co-Investigator)

Related Research

Grants with similar aims, by meaning.

BIOmimetic selective extraction MEMbranes
Continuous Separation of Solids, Liquids and Gases Using Membranes
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From membrane material synthesis to fabrication and function (SynFabFun)

Original classification

Research Grant

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