Completed Psychology & Behaviour Brain & Nervous System

The functional organization of directionally biassed feedback influences from MT to V1 and the LGN

In plain English

AI plain-English summary

The brain sends more signals back down the visual pathway than it receives from the eyes, and this project is trying to work out why. This matters because the standard view of vision treats it as a one-way street—light hits the eyes, signals travel to the thalamus, then to the cortex, and that is perception. But the cortex actually bombards the thalamus with feedback connections, and their function remains poorly understood. Without knowing what these backward signals do, we cannot fully explain how the brain constructs a stable, coherent visual world from noisy sensory input. This is fundamental science. It will not produce a new medical treatment or a better camera. But understanding how feedback circuits integrate motion processing across three levels of the visual system could reshape models of perception, attention, and sensory prediction. Similar fundamental work on feedback loops in the brain has previously informed treatments for visual neglect and tinnitus. A clearer picture of how higher brain areas tune lower ones may eventually guide interventions for conditions where perception breaks down—such as stroke-related visual deficits or motion blindness.

View original technical description
In the brain the pathways transferring sensory information from the sense organs, such as the eyes, to higher centers are matched by feedback pathways that run in the opposite direction. Thus the input from the eyes is relayed via a structure called the visual thalamus to the visual cortex, but the visual cortex sends feedback connections back down to the visual thalamus. Indeed numerically these exceed those arising from the eyes. Why does this happen? What do these connections do? They seem to bring the knowledge from the processing at higher levels in the brain back to earlier levels and in some way use this to enhance our ability to perceive the world around us. Here we are probing the role of the higher cortical area concerned with processing motion in the visual world and the way this area is linked into a functional circuit with the primary visual cortex and thalamus. The suggestion is that the feed forward and feedback connections linking three levels in the visual system operate as an integrated whole rather than as separate steps in a sequence.

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Researchers

Adam Sillito (Principal Investigator)Thomas Salt (Co-Investigator)

Related Research

Grants with similar aims, by meaning.

Function and Organization of Feedback Connections
Top-down and bottom-up selective mechanisms in attention: subcortical convergence in visual thalamus?
Characterizing spatial information in feedforward and feedback signals between mouse visual and navigational areas
Top-down control of visual processing and awareness: Studies with transcranial magnetic stimulation and electroencephalography.
Convergence of Information from Separate Brain Areas to Orchestrate Orienting Movements

Original classification

Research Grant

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