Completed Cancer Computing & AI

Evaluating new healthcare technologies in cancer

In plain English

AI plain-English summary

A single clinical trial programme will test new cancer drugs, artificial intelligence tools, and blood-based biomarkers simultaneously to speed up how quickly effective treatments reach patients. The problem is that evaluating new cancer therapies one at a time is slow. Patients may wait years for a promising drug to complete sequential trials. This programme compresses that timeline by testing multiple approaches—targeted drugs for genetically defined cancers, drugs that starve tumours by blocking blood vessel growth, and immuno-oncology drugs that help the immune system kill cancer cells—in parallel studies. It also tackles a practical bottleneck: radiotherapy planning is complex and time-consuming. Using artificial intelligence to automate treatment planning could allow many more patients to be treated sooner, and the approach could be deployed worldwide. If successful, the programme could change how cancer clinical research is conducted, making it faster and more efficient. Blood samples collected during the studies will be analysed with laboratory scientists and industry partners to understand how cancers develop and grow, feeding that knowledge back into future trial designs. The work is applied—it directly tests new technologies in patients—but it also generates fundamental biological insights that could inform cancer research for years to come.

View original technical description
Our aim is to reduce cancer deaths and the side effects associated with cancer treatments. We design clinical trials and other research studies that test several new approaches at the same time. This speeds up the evaluation of new therapies. In this programme we focus on new scientific developments. In particular new drugs that target cancers that have specific genetic markers, as well as drugs that prevent a cancer’s blood vessels developing. Cancers need new blood vessels to survive and grow. We are also testing the new immuno-oncology drugs. These drugs help the bodies’ immune system kill cancer cells. We will also test other new technologies such as artificial intelligence to improve cancer treatments. Artificial intelligence uses a computer’s power to do tasks that normally require human input. For example radiotherapy (x-ray treatment) can be used to cure cancers. But it is a complex and time consuming process to plan the treatment. It is important that the radiotherapy only targets the cancer and doesn’t harm healthy tissue near the cancer. Using a computer to speed up this process would potentially allow many more patients to be treated sooner. This could be used in countries all over the world. In our studies we collect blood samples from participants and work with laboratory scientists and industry partners to provide more knowledge about how cancers develop and grow. Where possible we use this information in our future studies.

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Researchers

Aleksandra Gentry-Maharaj (Co-Investigator)Angela Meade (Co-Investigator)Louise BROWN (Co-Investigator)Mahesh Parmar (Principal Investigator)Ruth Langley (Principal Investigator)Usha Menon (Co-Investigator)

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Original classification

Intramural

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