Active Infection & Immunity Genetics & Molecular Biology

Integrative viral genomics and bioinformatics platform

In plain English

AI plain-English summary

A UK-based team of virologists and data scientists is building a dedicated platform to analyse viral genomes and the diseases they cause, combining sequencing and computer analysis under one roof. This matters because genome sequencing has transformed how scientists track viruses, predict their evolution, and understand why some cause severe illness while others do not. But the expertise and computing power needed to make sense of viral genetic data are often scattered across different labs or borrowed from other fields. The new platform—unique in the UK for being entirely focused on virology—fills that gap by providing specialist knowledge, tools, and training to researchers nationwide. If successful, the platform will help scientists spot emerging viral threats faster, link genetic changes to real-world disease outcomes, and improve outbreak response. It will also support enhanced surveillance, feeding data directly into preparedness efforts. The work is largely fundamental science—building the infrastructure and methods to ask better questions about viral behaviour—but past investments in viral genomics have directly enabled rapid vaccine development and real-time tracking of pandemic spread.

View original technical description
Genome sequencing and associated computer-based analysis and methods have fundamentally transformed our understanding of viruses and the diseases they cause. The purpose of the integrative viral genomics and bioinformatics (iVGB) platform is to support CVR researchers and external collaborators across a range of virus-focused research projects, providing specialist expertise, resources and training to the wider UK and international virology community. The platform consists of the genomics and the bioinformatics teams, which work closely together. Uniquely in the UK, both teams are dedicated solely to virology and consist of experts in a wide range of topics relevant to the CVR research portfolio. Our research will be split into two overall objectives: (1) integration of genomic, evolutionary and phenotypic dimensions of viral infection (including the use of existing public data) in collaboration with the CVR research programmes and (2), with the Preparedness platform, response to outbreaks & enhanced surveillance

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Researchers

Ana Cristina Da Silva Filipe (Principal Investigator)David Robertson (Principal Investigator)

Related Research

Grants with similar aims, by meaning.

MRC-University of Glasgow Centre for Virus Research
MRC Centre for Genomics and Global Health
Virus Genomics for Outbreak Response (ViGOR) in Central/East Africa
European Virus Archive GLOBAL
High performance compute for CVR Preparedness platform

Original classification

Intramural

Plain English summaries and category classifications on this site are generated by AI and may not perfectly reflect the original research.