Active Cells, Biochemistry & Physiology Infection & Immunity

Structural biology and imaging platform

In plain English

AI plain-English summary

A new imaging platform lets researchers watch viruses in action, from the atomic jostle of individual molecules to the spread of infection through lung tissue. This matters because many fundamental steps of viral infection remain invisible. Scientists know viruses attach to cells, replicate, and spread, but they often cannot see exactly how the molecules involved change shape, evade immune defences, or assemble into new virus particles. The platform fills that gap by providing access to cryo-electron microscopes and other high-resolution tools, supported by expert technologists who help researchers design and interpret experiments. The research is primarily curiosity-driven fundamental science. It aims to answer basic questions about virus behaviour—how a virus enters a host cell, how cells build structures to trap viral genomes, and how virus populations move through an organ. There is no immediate practical application, but similar fundamental imaging work in the past has revealed the structure of HIV’s surface proteins, which later guided vaccine design. A clearer picture of viral mechanics could eventually inform drug targets or antiviral strategies, though that is not the project’s direct goal.

View original technical description
High-resolution imaging technologies are powerful tools to help us understand how viruses cause disease. The structural biology and imaging platform provides access to state-of-the-art tools to allow visualisation of viral processes, supported by expert technologists. The platform supports the investigation of virus behaviour across scales ranging from resolving the atomic structure of the molecules that virus particles (virions) are made up of and how they interact with those of the infected host, through to imaging viruses in infected tissues. These tools will be used by investigators in the CVR to understand e.g., how viruses can attach to and enter host cells, and how the molecules that perform this vital function evolve to avoid the host immune response; how cells can respond to the presence of a virus by for example making special structures to wrap up the viral genome and stop it expressing, or shutting down host processes that the virus needs to replicate; how populations of viruses can interact with each other as they move through an organ such as the lung; and how viruses assemble and leave an infected cell.

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Researchers

Chris Boutell (Co-Investigator)David Bhella (Principal Investigator)James Streetley (Co-Investigator)Joe Grove (Co-Investigator)Stephen Carter (Co-Investigator)

Related Research

Grants with similar aims, by meaning.

Structural studies of viruses and their interactions with cells
An integrative approach to deciphering the entry process in Herpesviruses
Opening new windows into viruses inside the cell by electron cryo-tomography (cryo-ET)
Membrane modulation in crucial virus-host interactions.
From molecules to tissues: Host-cell responses to infection

Original classification

Intramural

Plain English summaries and category classifications on this site are generated by AI and may not perfectly reflect the original research.