Four UK brain banks in Edinburgh, London, Newcastle and Oxford will supply human tissue samples—from both diseased and healthy brains—to researchers studying dementia, Parkinson’s disease, and motor neurone disease. Human tissue is essential for understanding what goes wrong in complex brain disorders. Animal models and cell cultures cannot fully replicate the intricate cellular environment of a living human brain. Without a steady supply of high-quality, ethically sourced post-mortem tissue, researchers cannot test their hypotheses about disease mechanisms or validate potential drug targets. The banks also collect normal tissue for use as controls, without which it is impossible to distinguish disease-specific changes from normal ageing. If this infrastructure continues to operate efficiently, it will accelerate the development of treatments for some of the most devastating neurological conditions. The banks have already contributed to existing therapies for Alzheimer’s and Parkinson’s diseases. By maintaining a publicly searchable online database of available samples and reducing the time needed to fulfil requests, the network removes a major bottleneck in neuroscience research. The operating costs of these four UK banks are lower than comparable facilities in Europe and the United States, making them a cost-effective backbone for national research priorities.
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This application plans to support research into the causes and potential treatment of a range of diseases affecting the brain, some of which have been identified as priorities for research, such as dementia. The UK has a network of established Brain Banks that provide human tissue samples to a wide range of researchers. Human tissue samples have allowed a better understanding of the mechanisms operating in these complex disorders and have already aided the development of treatments for Alzheimer's disease and Parkinson's disease. This application will support four Brain Banks in Edinburgh, London, Newcastle and Oxford. These banks each have areas of particular interest, Parkinson's disease, Alzheimer's disease and motor neurone disease. However, in addition to the collection of tissues samples from patients with brain disorders, it is also essential to collect normal tissue samples for use as controls in research. Two of the Banks have a major focus in this area, so this application will support the collection of both disease and normal tissue samples. The banks will support scientific research by providing human tissue samples in an efficient and cost effective manner, while ensuring the samples provided are of the high quality required by researchers. The banks have worked to improve their efficiency, reducing the time required to provide the samples to researchers. Details of the samples available in each of the banks are included in a database, which is accessible through the internet. This allows researchers to see what samples are available and how to request these samples for their research in an easy way that will save time and speed up progress. All four Brain Banks in this application have approval form an Ethics Committee, to ensure that their working practices meet nationally agreed standards that apply to work with human tissue samples. The work of each Bank is overseen by a local steering committee that includes members of the public and ethics experts as well as scientists and pathologists. Brain Banking is expensive, but the operating costs of these four banks are far less than their equivalents in Europe and in the USA. The challenges of developing treatments for complex diseases such as Alzheimer's disease and Parkinson's disease are considerable, but the Brain Banks in this application will play an important role in underpinning the scientific research in these national priority areas.
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