PREDICT-TR - Predicting outcomes after intervention in tricuspid regurgitation Predicting functional and clinical outcomes following transcatheter tricuspid valve intervention for severe tricuspid regurgitation

A new keyhole procedure to fix a leaky heart valve works well for some patients but not others, and doctors cannot yet predict who will benefit. Severe tricuspid regurgitation—where blood flows backward through the valve on the right side of the heart—raises the risk of death. Until recently, the only option was open-heart surgery, which is too risky for many frail or elderly patients. Newer transcatheter techniques, such as clip repair or valve replacement, offer a less invasive alternative. But roughly a third of patients see little improvement, and the reasons are poorly understood. This study aims to identify which patients will respond well before the procedure begins. The research team will use non-invasive scans and pressure measurements taken during the intervention to track how the heart’s pumping function changes afterward. They will focus on two distinct forms of the disease—atrial and ventricular tricuspid regurgitation—which may respond differently to treatment. If successful, the work could give clinicians a simple, scan-based way to select the right patients for the right procedure. That would reduce the number of people who undergo an invasive intervention with little benefit, and improve survival and quality of life for those who do receive it.