Risk of Cancer and Hyperplasia in Thickened Endometrium Without Postmenopausal Bleeding: a prospective multicentre study

This study aims to determine the womb lining thickness that might suggest cancer or precancer in women after menopause who have no vaginal bleeding but the internal scan showed that the womb lining to be thicker than 4 mm. It is well established that women who bleed after the menopause require further investigations if the internal scan shows a womb lining thickness more than 4mm; however, it is uncertain as at what womb lining thickness postmenopausal women without bleeding should be offered further intervention. The practice varies in different hospitals, hence the need for this study. Cancer of the lining of the womb is the fourth most common cancer in females in the United Kingdom. Although women with postmenopausal bleeding are the most vulnerable, sometimes it develops in postmenopausal women with no bleeding. Many postmenopausal women without vaginal bleeding have internal scans for symptoms such as tummy pain or urinary problems. There is no agreement among health professionals as regards the thickness of the womb lining that may suggest cancer or precancer. This is an observational study meaning we will only collect the data related to the standard routine care being delivered within the NHS.