Completed Cancer Engineering

New minimally invasive technologies for the treatment of pancreatic cancer

In plain English

AI plain-English summary

Pancreatic cancer kills 95% of patients within two years, and this project aims to replace the current limited treatment options with tiny magnetic robots that can crawl through the organ's delicate interior without cutting it open. The problem is that the pancreas is buried deep in the abdomen, wrapped around major blood vessels, and so sensitive that surgery often causes severe side effects or is impossible. Current treatments—chemotherapy and invasive surgery—offer little hope. The researchers propose building microscale, magnetically-driven soft robots that can be steered through natural pathways to deliver drugs or other therapies directly to tumours. This would avoid the collateral damage of surgery and systemic chemotherapy. If the technology works, it could transform pancreatic cancer from a death sentence into a manageable condition. The same approach might eventually be adapted for other hard-to-reach cancers. The project also prepares for a future where earlier diagnosis becomes possible—because detecting tumours sooner will be useless without equally precise, non-destructive ways to treat them.

View original technical description
Our vision is to challenge the mind-set of pancreatic cancer being a prognosis of extremely limited options and to enable revolutionary future treatments that will save lives and allow patients to live without major side-effects. Novel engineering and physical science has an essential contribution to make against what is currently the deadliest form of cancer (mortality 95% <2yrs). This research will centre around the creation of new minimally-invasive technologies based on microscale, magnetically-driven, soft continuum robots. These will newly enable non-destructive access to the intricate sensitive internal anatomy of the pancreas and allow targeted treatments to be delivered. These new technologies will tackle current clinical challenges in pancreatic cancer, while also providing the treatment methods that will be required as possibilities for earlier diagnosis emerge in the future.

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Researchers

Giuseppe Tronci (Co-Investigator)Harvey Thompson (Co-Investigator)Jaemin Lee (Co-Investigator)Pietro Valdastri (Co-Investigator)Russell Harris (Principal Investigator)Stephen Russell (Co-Investigator)Thomas Pike (Co-Investigator)

Related Research

Grants with similar aims, by meaning.

MICA: PANC-AID: Engineering a novel dynamic pancreatic cancer organoid model (MICA)
Biophysics of cancer: modelling and assessing physical resistance to therapy
Self-propelled soft robotic endoscopes for next-generation gastrointestinal surgery and beyond
Micro-Robotics for Surgery
Machine-learning guided experimental approaches for developing a robust nanoscale delivery platform for the treatment of pancreatic cancer

Original classification

Research Grant

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