Fruit flies carry an internal 24-hour clock that controls everything from their cells to their behaviour, and a new training network will teach doctoral students how to manipulate that clock for practical ends. The same genetic clockwork that won a Nobel Prize in 2017 also governs how insects enter seasonal hibernation (diapause), pollinate crops, become pests, and grow as a sustainable protein source for human food and animal feed. As the climate warms, insects shift their ranges—and their diapause timing determines whether they survive new environments. Current knowledge of the insect clock comes almost entirely from one lab species, *Drosophila melanogaster*. INCITE will train researchers to study the clock across multiple insect species, connecting fundamental molecular biology to real-world applications. If the network succeeds, it will produce graduates who can apply clock biology to improve mass-rearing of insects for food, develop more targeted pest control strategies, and predict how pollinators and pests will respond to climate change. The project is primarily a training initiative, but the comparative approach will also advance fundamental circadian science—the kind of basic knowledge that, as the 2017 Nobel showed, can eventually transform medicine, agriculture, and ecology.
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Organisms that inhabit the surface of the Earth have evolved an endogenous 24 hour clock that infiltrates every level of biological organisation from the molecular to the ecological. This biological timer is a critical adaptation to living on a rotating planet with predictable daily and seasonal cycles of light and dark, warmth and cold. The fruitfly Drosophila melanogaster has provided the model system by which the highly conserved genetic and molecular basis of animal rhythmicity was initially dissected, winning a Nobel Prize in 2017 to its discoverers. Our network INCITE (INsect Clock Initial Training Experience) will provide state-of-the-art doctoral training to doctoral candidates (DCs) in insect molecular chronobiology using a comparative approach in which the circadian clock will be studied from a variety of perspectives. These will include the recruitment of the clock for i) insect seasonal 'hibernation' or diapause, a critical life-history feature that has important implications for range expansion under global warming, ii) in pollination, ii) in pest control, iv) in optimising the development of insects mass-reared as a protein source for human/animal consumption- a sustainable model for agriculture and vi) in fundamental circadian biology of the model insect, D. melanogaster. In addition to their research projects, DCs will be seconded to partners both academic and industrial within the network and be further exposed to a variety of successful well-defined and time-tested courses that supplement those already offered at their local institutions, and will enhance and develop their scientific, entrepreneurial and transferable skills. INCITE will generate highly-trained, mobile and employable graduates that will be welcomed both in academia and industry.
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