Active Psychology & Behaviour Brain & Nervous System

Integrating cognition and systems neuroscience to understand child development

In plain English

AI plain-English summary

A child’s brain does not develop on a fixed timetable—the emergence of long-range neural networks varies dramatically from one individual to the next, and scientists do not yet understand why. This programme tackles that gap. Researchers will combine brain imaging data with computational models inspired by artificial intelligence to map how brain networks become specialised for different cognitive functions across childhood and adolescence. They want to know whether the wide variability in brain development aligns with existing psychiatric diagnostic categories, and whether simple biological principles can explain complex developmental patterns. If successful, the work could reshape how clinicians interpret developmental differences. Instead of relying solely on behavioural symptoms or diagnostic labels, doctors might one day use brain network data to identify atypical trajectories earlier and more precisely. The research is primarily fundamental science—it asks how the brain organises itself over time—but a deeper understanding of these mechanisms could eventually inform more targeted interventions for conditions such as autism, ADHD, or schizophrenia. Past work in systems neuroscience has shown that mapping basic organisational principles often opens unexpected routes to clinical tools.

View original technical description
The human brain has a characteristic organisation. This organisation emerges early in life, even before we are born, and continues to change through adolescence and into early adulthood. The emergence and continual refinement of brain networks, connecting different regions of the brain across large distances, allows for increasing ‘functional specialisation’. That is, these networks become more dedicated to particular cognitive processes. But this gradual process of network emergence is incredibly variable across individuals, and it is not clear why this diversity exists, what consequences it holds for cognition, or what factors might shape it over time. The purpose of this programme is to address these gaps in our understanding. We develop and apply multiple different analysis tools, including computational models inspired by artificial intelligence, and integrate these with brain imaging data. This combination allows us to unpack typical and atypical developmental processes. This allows us to address the following questions: Firstly, how do we capture the incredible variability in brain development that exists across childhood and adolescence, and does this variability map to established diagnostic categories? Secondly, can we build developmental models that formalise simple biological principles in order to capture complex developmental phenomena? Thirdly, can we use these models to bridge scales and species to establish fundamental and causal mechanisms that shape development?

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Researchers

Duncan Astle (Principal Investigator)

Related Research

Grants with similar aims, by meaning.

Modelling the Development of Complex Brain Networks
Modelling Human Brain Development
A Longitudinal Multi-Layered Approach to Cognition Across Childhood and Adolescence
What makes your mind unique? Tailoring brain network models to individuals to enhance predictions of neurological development and disease.
Early development of cerebellar and cerebro-cerebellar connectivity

Original classification

Intramural

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