A single PCR test for COVID-19 can cost as little as 40 pence when samples are pooled and processed at scale, rather than tested individually. The TestEd programme at the University of Edinburgh addresses a practical problem that became acute during the pandemic: how to test large populations—such as university staff and students—frequently enough to catch asymptomatic carriers before they spread the virus, without bankrupting the institution. Current individual testing strategies are too expensive for twice-weekly screening of tens of thousands of people. The researchers will compare two pooling methods—PCR-based hypercube pooling and sequence-based SwabSeq—against individual tests on at least 10,000 samples, then use the better method to test half a million samples over 12 months. They will also survey participants and model the health economics of the entire pipeline. If successful, the project will produce a blueprint for affordable, large-scale regular testing that could protect workplaces and communities during future pandemics. The system’s logistics—including robotic automation and 24-hour turnaround—are designed to be deployable beyond universities, potentially influencing national policy and practice.
View original technical description
The TestEd programme at the University of Edinburgh will develop and evaluate an affordable whole system approach for early detection of COVID-19 that will provide a blueprint for large-scale regular testing to protect workplaces and communities from COVID-19 and, potentially, future pandemics. Specifically we will: - Implement our system that has now been established in two Institutes of the University of Edinburgh for streamlined, effective and accessible participant and sample registration, COVID-19 based on novel sample pooling strategies, automated, timely feedback of results, across the entire University of Edinburgh population, for twice weekly testing and rapid isolation of asymptomatic carriers - Conduct online surveys of all participants, and qualitative interviews on those who test positive for the virus, to understand attitudes and behaviour in the face of the pandemic, and the views of staff and students regarding regular testing and the potential need for self-isolation - Carry out health economic modelling of the pipeline, including our strategy to test for the virus in pooled samples that our preliminary analyses (see Additional Information Form) have shown have the potential for tests costing 40p per sample, at least ten-fold lower than other testing strategies - Evaluate efficacy and efficiency of the two pooling strategies - PCR-based hypercube pooling and sequence-based SwabSeq - by side-by-side comparison of their performance against individual PCR tests on a minimum of 10,000 samples and then, by using the pooling strategy with better performance, to test half a million samples collected from University staff and students within the 12 month period of the award - Engage with our collaborators within and outside the University to optimise the logistics of our laboratory processes, thereby minimising the time of each laboratory step and hands-on lab staff time, maximising use of robotic automation, thereby minimising overall turnaround time. Our current turnaround time is 100% return of results within 24 hours of the end of the 8-hour sample collection period. We shall monitor this through the course of the study period, providing reports to our participant community and to the MRC, aiming to remain as close as possible to 100% return of results within 24 hours throughout scale up and to full testing capacity - Engage with our participant community, the University leadership team, our collaborators within the NHS, our collaborators providing equipment and reagents and Edinburgh Innovations (our technology transfer organisation) to develop opportunities for future funding and deployment of our pipeline and knowhow within and outside the University at the conclusion of the funding period. This includes the opportunity to work with Government and non-governmental organisations to influence policy and to deploy our system, knowledge and experience to other workplaces and communities - Engage with policymakers and healthcare providers to ensure that our results and experience with large-scale testing can be fed into national and possibly international policy and practice for pandemic responses.
Plain English summaries and category classifications on this site are generated by AI and may not perfectly reflect the original research.
Is something wrong? Let us know