Active Materials & Manufacturing Engineering

Exotic isotope production for medical applications

In plain English

AI plain-English summary

A new ion source and electromagnetic mass separator will be built to produce rare radioactive isotopes that are currently in short supply for cancer treatment and medical imaging. The problem is straightforward: many promising medical isotopes—such as actinium-225 for targeted cancer therapy—are difficult to obtain in sufficient quantities. Global supply is shrinking as nuclear research reactors are decommissioned, while demand for both established and experimental isotopes continues to rise. Without reliable production methods, clinical trials and eventual treatments cannot move forward. This project develops the hardware needed to create and purify these exotic isotopes in the laboratory rather than relying on ageing reactors. If successful, it could secure a domestic supply chain for isotopes used in therapies that kill tumour cells with precision, and for imaging agents that help diagnose disease earlier. The work focuses on producing pre-clinical amounts for initial studies, laying the groundwork for scaled-up production later. This is applied engineering for a specific medical bottleneck. It does not explore fundamental nuclear physics for its own sake, but directly addresses a practical shortage that currently limits what doctors can offer patients.

View original technical description
Radioactive isotopes have ratio of protons and neutrons that results in their instability. This presents both a plethora of opportunities, and a challenge to obtain them due to their finite nature. This work seeks to meet the rising medical demand for these exotic isotopes, through the development of new technologies and approaches for radioactive isotope production and separation. While the use of established medical isotopes is growing, there are challenges to the supply as nuclear research reactors are decommissioned across the world. Additionally, the application of non-standard isotopes such as 225Ac have shown significant promise for the treatment of cancers, while others have applications in medical imaging. Reliable processes for the production and separation of these isotopes are required to realise the full potential of these applications and to produce pre-clinical amounts for initial studies. This work seeks to address this through ion source and electromagnetic mass separator development for exotic medical isotope production.

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Researchers

Thomas Day Goodacre (Principal Investigator)

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Original classification

Fellowship

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