Completed Genetics & Molecular Biology Pregnancy, Children & Inherited Conditions

Genetics of the people of the british isles and their faces.

In plain English

AI plain-English summary

The researchers are collecting DNA and photographs from thousands of volunteers across the British Isles to map how ancestry shapes facial features and to trace the genetic history of the population. This project fills two gaps. First, the genetic makeup of the British Isles is a patchwork of ancient migrations—Celtic, Anglo-Saxon, Viking, Norman—but the fine-grained regional patterns remain poorly understood. Existing samples are biased toward rural areas; the new collection targets the western fringe and eastern Anglo-Saxon heartlands, plus surrounding populations, to fill in missing pieces. Second, the genetic basis of normal facial variation is largely unknown. By linking facial measurements from photographs to DNA markers, the team aims to identify the specific genes that influence nose shape, cheekbone structure, and other features. If successful, the work could improve forensic DNA profiling—predicting a suspect’s appearance from crime-scene samples—and help correct for population structure in medical genetics studies, where subtle ancestry differences can confound disease-gene associations. The fundamental science is curiosity-driven: understanding how a small number of genes build a recognisable human face, and how centuries of migration have layered that genetic information across the British landscape.

View original technical description
We will add 1,000 samples from the Ancient British western fringe, and from the eastern areas that most reflect the Anglo-Saxon influence, to the 3,500 already collected (rural areas, all four grandparents from the same area). A further 1,500 samples will be collected from populations surrounding the British Isles. Genetic variation determining facial features will be identified through association analysis of candidate gene markers with statistically determined facial characteristics obtained from photographs of the newly collected volunteers and of MZ and DZ twins from the TRU study. Lymphoblastoid cell lines will be grown out from a subset of 1,000 individuals to enable study of the genetic control of tissue specific protein and mRNA levels. Surname distributions will be used to enhance information about the locality of volunteers. Extensive genotyping will be done on the new samples. Analysis of the results of this and previous genotype data, using machine learning algorithms a nd second level haplotyping, together with the facial genetic and certain other markers, will be used to construct a panel of highly informative AIMs. These will be typed on all samples and form the basis for an extensive analysis of population substructure using a wide variety of statistical approaches.

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Researchers

Walter Bodmer (EPMC Awardee)

Related Research

Grants with similar aims, by meaning.

Whole-genome history and evolution in a thousand ancient Britons
Development of Bayesian methods for genetic epidemiology
Genes & Health: a population based DNA sequencing, medical records, and recall BioResource study of British-Bangladeshi and British-Pakistani communities.
Genetic investigation of life course phenotypes of mental health and illness in the 1946 British birth cohort
The genetics of human physical appearance

Original classification

Programme Grant

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