| WTSI Science and IT Platforms, Translation, Administration and Estates | Wellcome Sanger Institute | Wellcome | £518.8M | 2016 | Completed |
| Wellcome Leap Inc. Additional Funding to Main Award | Wellcome Leap | Wellcome | £465.8M | 2024 | Active |
| Wellcome Sanger Institute Quinquennial Review 2021-2026 | Wellcome Sanger Institute | Wellcome | £342.2M | 2021 | Active |
| Phase 3 trial to assess M72/AS01E-4 Mycobacterium tuberculosis (TB) vaccine | Gates Foundation | Wellcome | £126.0M | 2023 | Active |
| The Malawi Liverpool Wellcome Research Programme | Malawi Liverpool Wellcome Programme | Wellcome | £109.5M | 2025 | Active |
| Using statistical and mathematical modelling to establish the transmission dynamics and burden of visceral leishmaniasis in Kenya and Ethiopia to inform targeted control and elimination strategies | Associated with International Livestock Research Institute, Kenya · Kenya Medical Research Institute (KEMRI) · Misc Ethiopia · University of Nairobi · University of Oxford · Washington State University | Wellcome | £6.9M | 2026 | Active |
| Molecular annotation of the Drosophila connectome by optimised expansion microscopy | Associated with Howard Hughes Medical Institute · Ukri-Mrc | Wellcome | £6.6M | 2026 | Upcoming |
| FUTURE-D = Forecasting Depression Trajectories: Early Network-Guided Prediction of Severe and Persistent Disease Courses | Goethe University Frankfurt | Wellcome | £5.2M | 2026 | Active |
| Enigmatic bacterial sphingolipids; elucidating their biosynthesis, transport and function within the host. | Associated with Newcastle University · University of Edinburgh · University of Oxford | Wellcome | £5.0M | 2026 | Active |
| Seeing inside the brain: the in-tissue structure of living and postmortem Alzheimer’s disease human donor brain by high-resolution cryo-electron tomography. | Associated with University College London · University of Leeds | Wellcome | £4.8M | 2026 | Upcoming |
| Myeloid Inhibitory C-type lectin-like receptor (MICL, CLEC12A) – a central regulator of immunity | University of Exeter | Wellcome | £4.7M | 2026 | Active |
| “B-ZERO” - Accelerating progress towards HBV elimination in Africa by using treatment to deliver aviraemia | Associated with Addis Ababa University · Stellenbosch University · The Francis Crick Institute · University of Bristol · University of Oslo | Wellcome | £4.1M | 2026 | Active |
| A Multidisciplinary Bioimaging Platform for Quantitative Force Mapping in the Beating Heart | Associated with Imperial College London · University of Glasgow · University of Sheffield | Wellcome | £4.1M | 2026 | Active |
| Kinase-phosphatase cooperativity on individual molecules during the cell cycle | Associated with Max Planck Institute · University of Dundee | Wellcome | £4.0M | 2026 | Upcoming |
| CRITICAL SEEING: using film, ethnographic, and deliberative methods to form multimodal representations of ICU decision-making dispute, and to model practices of conflict reduction | Associated with Central and North West London NHS Foundation Trust · Imperial College London · King's College London · Queen Mary University of London · The Open University · University College London · University College London Hospitals NHS Foundation Trust | Wellcome | £3.7M | 2026 | Active |
| Institutional practices, community action, and individual resistance: Understanding the mechanisms generating LGBTQ+ health inequities | Associated with Consortium of Lesbian, Gay, Bisexual and Transgender Voluntary and Community Organisations · King's College London · The Outside Project · University College London | Wellcome | £3.4M | 2026 | Upcoming |
| Strengthening Adolescent Resilience to Improve Sexual and reproductive hEalth (ARISE) Uganda | London School of Hygiene & Tropical Medicine | Wellcome | £3.4M | 2026 | Active |
| How are bunyavirus replication factories built? | Associated with Biofisika Institute · Catolica Biomedical Research Centre · University of Leeds | Wellcome | £3.3M | 2026 | Active |
| Shedding new light on tissue mechanobiology with multimodal multiphoton nano- rheology microscopy | Associated with Cardiff University · University of Cambridge | Wellcome | £3.2M | 2026 | Upcoming |
| Exploiting rhomboid-like proteins to control signalling | University of Oxford | Wellcome | £3.0M | 2026 | Upcoming |