Completed Bones, Joints & Muscles Heart, Stroke & Blood

Engineering Solutions for an Ageing Population with Musculoskeletal & Cardiovascular Disease. 50 more years after 50.

In plain English

AI plain-English summary

People in their fifties today expect another fifty active years, but ageing joints, hearts, and blood vessels threaten that future. This matters because the UK’s ageing population is growing rapidly, and current treatments for worn-out hips, knees, spines, and cardiovascular tissues are limited. Joint replacements wear out, damaged cartilage does not heal on its own, and heart valves or arteries can degenerate beyond repair. WELMEC brings together over 200 engineers, biologists, clinicians, and industrialists to tackle these problems as a single integrated programme, rather than in isolated projects. If successful, the research could deliver longer-lasting hip, knee, and spine replacements that reduce the need for revision surgery. It could produce biological scaffolds that guide a patient’s own stem cells to regrow damaged joint tissue, dental bone, or cardiovascular structures. Earlier diagnosis through advanced imaging and protein biosensors would allow doctors to intervene before degeneration becomes irreversible, preserving healthy tissue and tailoring treatment to each patient. The result would be a shift from reactive repair to proactive, personalised care—keeping people mobile, working, and independent for decades longer than current medicine allows.

View original technical description
The ageing population is increasing in number and life expectancy. The population expects fifty more years after fifty with high levels of activity and quality of life. However, the musculoskeletal and cardiovascular systems age and degenerate, adversely affecting mobility, ability to work and quality of life. Advances in engineering and bioscience have created opportunities for novel devices and regenerative therapies, which utilise innovative biomaterials or biological scaffolds to guide the patient's own stem cells to repair degenerative tissues. Advances in patient imaging and diagnostics are enabling earlier disease diagnosis with opportunities to intervene earlier in the degenerative process and preserve healthy tissue, and potential to provide patient specific continuum of care. WELMEC will deliver: - Longer lasting joint replacements in the hip, knee and spine. - Novel regenerative biological scaffolds for degenerative joint tissues, dental reconstructions and cardiovascular surgery. - Advances in cell therapies using the patient's stem cells. - Advanced medical imaging to facilitate earlier diagnosis and intervention. - Novel protein biosensors for disease diagnosis and improved patient targeting. WELMEC will integrate over 200 engineering, physical science, life science and medical researchers with clinicians and industrialists to develop and deliver innovative therapies and patient services for the ageing population.

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Researchers

John Fisher (EPMC Awardee)

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Original classification

Programme Grant

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