Completed Brain & Nervous System

Core support for the Wellcome Trust Centre for Neuroimaging

In plain English

AI plain-English summary

A single mathematical framework is being built to unite every major way of scanning the living human brain—from fMRI and MEG to direct recordings from inside the skull. The problem is that neuroscience currently lacks a common language. Researchers studying a mouse’s local field potentials, a patient’s EEG, and a volunteer’s fMRI scan all use different analytical tools, making it nearly impossible to compare findings or translate animal results into human treatments. This centre aims to create a single, model-based system that can handle all these data types, from animal recordings through to patient studies. If successful, this work would give both fundamental and clinical neuroscience a shared toolkit. The immediate impact is on how research is done—faster, more rigorous comparisons across species and methods. The deeper payoff, however, is tackling the hardest problems in the field: understanding exactly how neuronal function breaks down in common neurological and psychiatric disorders. This is primarily fundamental science, building the conceptual infrastructure that future diagnostics and treatments will depend on.

View original technical description
In seeking to renew the Wellcome Trust Centre for Neuroimaging (WTCN) we have developed a scientific strategy based on promoting diverse research themes that all rest on understanding brain function in terms of formal models. More specifically, our aim is to develop models that provide a generic framework for the analysis of in-vivo brain data that critically includes fMRI, MEG and EEG data (the principal modalities used by the Centre PI's), but also data acquired from direct human inter-crania l recordings and animal based local field potential data. Our aim is to furnish basic and clinical neuroscience with common, model based, frameworks capable of integrating findings from animal recordings through to patient studies. In this context our overarching goal is to extend the range and depth of the neuroscientific questions we address by promoting a scientific vision with sufficient maturity to tackle the most difficult problems in neuroscience, namely the breakdown in neuronal functi on that characterises common neurological and neuropsychiatric disorders.

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Researchers

Raymond Dolan (EPMC Awardee)

Related Research

Grants with similar aims, by meaning.

Wellcome Centre for Integrative Neuroimaging
Integrated multimodal brain imaging for neuroscience research and clinical practice.
Integrative imaging of brain structure and function in populations and individuals
Oxford Centre for Human Brain Activity.
High-resolution multimodal imaging for multisensory interactions

Original classification

Wellcome Trust Centre

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