Completed Heart, Stroke & Blood Lungs & Breathing

Totally automated blood pressure monitoring at home to improve care of patients with Heart Failure or Pulmonary Hypertension.

In plain English

AI plain-English summary

A permanent pressure sensor implanted in the heart’s pulmonary artery lets patients with heart failure or pulmonary hypertension monitor their condition daily from home, replacing risky and expensive hospital catheterisations. Current treatment for chronic heart failure relies on drugs like diuretics and beta-blockers, but individual responses vary widely. Patients require frequent clinical reviews to adjust doses, and when stability fails, they are re-hospitalised—a pattern linked to high mortality. The most reliable measure of disease control, pulmonary artery pressure, currently requires cardiac catheterisation, an invasive procedure too risky and costly to repeat often. This project proposes placing a permanent pressure-sensing implant during the first catheterisation, then transmitting pressure readings wirelessly via a mobile health link while the patient goes about normal activities. If successful, the implant would give patients immediate warning of deteriorating condition, allowing faster treatment adjustments and fewer hospital admissions. Clinicians would gain continuous, dynamic pressure data—far more informative than a single reading taken in a hospital bed. For the health service, this could mean fewer consultations, fewer invasive procedures, and more precise drug titration. The technology also creates an unprecedented tool for assessing how different treatments affect real-world patient responses.

View original technical description
The treatment of Chronic Heart Failure is designed to retard the progression of the disease and to relieve its disabling symptoms using a combination of diuretics, ACE inhibitors or ARB's, and beta-blockers. Individual responses vary and continuing clinical review is essential, titrating drug doses to achieve stability without side-effects. Failure results in re-hospitalisation to regain stability, and is associated with a high mortality. For both Heart Failure and Pulmonary Hypertension patients achieving and maintaining a low Pulmonary Artery Pressure, measured by cardiac catheterisation, is desired as the most significant control variable. Catheterisation is a risky, acute and expensive procedure, rarely used repeatedly; we propose placement of a permanent pressure-sensing implant during the first catheterisation, avoiding future procedures and allowing continuous monitoring of PAP at home via a wireless mHealth link, while engaged in normal activities. The information from dynamic PAP is better than from a single measure in a hospital bed or clinic. The individual patient will have the assurance of immediate response to changes in their condition; treatment will be more accurate; new data on patient responses, different treatments and new treatments will have an unparalleled assessment tool. The Health Service provider will need fewer consultations and procedures.

View the original record at the funder ↗

Researchers

Chris McLeod (EPMC Awardee)Lionel Tarassenko (EPMC Awardee)

Related Research

Grants with similar aims, by meaning.

Long-term home monitoring of Heart Failure patients for improved care and reduced hospitalisation
Comprehensive remote monitoring system for Congestive Heart Failure
heaRt failurE paTient managEment and iNTerventIOns usiNg continuous patient monitoring outside hospitals and real world data
FIT PH: Feasibility of Novel Clinical Trial Infrastructure, Design and Technology for Early Phase Studies in Patients with Pulmonary Hypertension
Addition of Continuous Cardiac Output measurements to improve care of chronic cardiac patients at home

Original classification

Health Innovation Challenge Fund Award

Plain English summaries and category classifications on this site are generated by AI and may not perfectly reflect the original research.