Completed Brain & Nervous System Heart, Stroke & Blood

MRI award - Imaging

In plain English

AI plain-English summary

UK Biobank is scanning the brains, hearts, and blood vessels of 100,000 middle-aged volunteers with MRI, ultrasound, and X-ray machines. This matters because most large health studies rely on questionnaires and blood samples, which miss the physical changes in organs that precede disease. UK Biobank already tracks 500,000 people aged 40–69 through health records, but only a small fraction develop any given condition. Adding detailed scans to 100,000 participants creates a massive library of images that show what healthy and diseased organs actually look like in living people. The imaging data will define measurable traits—such as heart chamber size or artery stiffness—that are directly linked to illness. If this succeeds, researchers will be able to detect disease earlier and more reliably. Instead of waiting for someone to have a heart attack or stroke, doctors might one day spot the warning signs in a routine scan years beforehand. The project also provides a shared resource for scientists worldwide, ensuring consistent definitions of disease across studies. This is primarily a data-collection effort, not a clinical trial, but the resulting imaging database could transform how we predict and prevent common conditions.

View original technical description
Prospective cohorts, such as UK Biobank, have advantages for the comprehensiveand reliable quantification of the combined effects of different types of riskfactor on disease. However, they need to involve large numbers of participantsbecause only a relatively small proportion will develop any particular condition. UK Biobank has collected extensive baseline questionnaire data, physical measures and biological samples from 500,000 men and women aged 40-69at baseline and their health is being followed by linkage to health records. Central adjudication of health outcomes will ensure that consistent definitions are used and facilitate access to the resource. It is now planned to enhance further the phenotyping of 100,000 participants with information from multiple imaging modalities involving Magnetic Resonance imaging of brain, heart, large blood vessels and abdomen, Ultrasound of carotid arteries,and Dual-Energy X-ray Absorptiometry (DXA) of bone and joints. The availability of imaging measures that quantitatively define phenotypes that are closely related to disease will provide substantial power for detecting

View the original record at the funder ↗

Researchers

Rory Collins (EPMC Awardee)

Related Research

Grants with similar aims, by meaning.

UK Biobank pilot imaging enhancement
UK Biobank Imaging Enhancement Main phase
Creation of cardiovascular magnetic resonance imaging reference standard for the UK Biobank imaging resource
Mitochondrial biogenesis and disease
Integrative imaging of brain structure and function in populations and individuals

Original classification

Strategic Award - Science

Plain English summaries and category classifications on this site are generated by AI and may not perfectly reflect the original research.