Completed Cells, Biochemistry & Physiology Genetics & Molecular Biology

Micron Oxford: super-resolution imaging of cellular dynamics.

In plain English

AI plain-English summary

Oxford biologists will get early access to the most technically challenging imaging technologies before those tools reach the wider research community. This matters because seeing how cells behave in real time—at the level of single molecules—requires microscopes that don't yet exist commercially. Most advanced imaging methods work on dead or fixed samples, which miss the dynamic processes that drive development, disease, and healthy function. Micron coordinates the engineers who build new microscopes with the biologists who need them, closing a gap that typically slows discovery by years. If the project succeeds, researchers across the UK and worldwide will adopt these complex imaging technologies for their own work. The immediate impact will be on fundamental science: understanding the basic molecular mechanisms that govern how cells divide, move, and communicate in health and disease. This is curiosity-driven research with no direct practical application today, but similar investments in advanced microscopy have historically enabled breakthroughs in drug development, cancer biology, and regenerative medicine that were impossible to predict at the time.

View original technical description
Micron's major goal is to develop and apply the next generation of advanced microscopy methods to facilitate transformational discoveries in cell and developmental biology at Oxford and in the UK. Micron will coordinate and manage the inter-departmental and interdisciplinary cooperation and synergies required to achieve this goal. It will enable Oxford biologists to become early adopters of the most advanced and technically challenging imaging technologies. Micron has already established an o utstanding track record in facilitating collaborations between microscopy technology developers and biologists across Oxford. This Strategic Award will allow Micron to maintain its position as one of the worlds leading sites for the development and application of the many new forms of advanced microscopy, with a particular emphasis on live super-resolution and single-molecule microscopic imaging. The Strategic Award will provide added value to the considerable existing Wellcome Trust investment in individual biomedical investigators in Oxford, and will also facilitate the adoption of complex imaging technologies by other researchers across the UK and worldwide. Thus, Micron will have a significant impact on the Trust's strategic aim of understanding basic molecular mechanisms in cell and developmental biology in health and in disease.

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Researchers

Ilan Davis (EPMC Awardee)

Related Research

Grants with similar aims, by meaning.

MICA: Nanoscopy Oxford (NanO): Novel Super-Resolution Imaging Applied to Biomedical Sciences
High speed super-resolution imaging with the OMX microscope.
MICA: A super resolution optical microscopy facility at the MRC Laboratory of Molecular Biology.
A super-resolution multi-scale in vitro and in vivo imaging platform at Harwell: building models of development and disease from molecules to mammals
Using super-resolution live cell imaging to understand the dynamics of disease

Original classification

Strategic Award - Science

Plain English summaries and category classifications on this site are generated by AI and may not perfectly reflect the original research.