Active Genetics & Molecular Biology Cancer

Advanced therapies for regenerative medicine

In plain English

AI plain-English summary

A new training programme at King’s College London will embed PhD students directly into the laboratories and clinics that are turning cell transplants, gene therapies, and tissue repair techniques into real treatments for patients. Regenerative medicine—repairing or replacing damaged organs and tissues—has long promised to transform how we treat heart disease, blindness, and degenerative conditions. But the field has struggled to move discoveries from the lab bench to the bedside. The bottleneck is not just scientific: it is a shortage of researchers who understand both the fundamental biology and the practical steps needed to manufacture therapies, run clinical trials, and navigate commercial pathways. This programme tackles that gap head-on. Students spend their first year rotating through three different labs while taking taught courses and master classes, earning an MRes before committing to a three-year PhD project. Supervisors span clinical and non-clinical disciplines, from early-career to senior researchers. Partner organisations offer secondments for additional real-world training. If it succeeds, the programme will produce a cohort of scientists fluent in translation—able to design a gene therapy in the lab and understand what it takes to deliver it to a patient. Over time, that could accelerate the pipeline of regenerative treatments reaching the NHS.

View original technical description
The goal of the programme is to train a new generation of researchers in the advanced therapies that underpin regenerative medicine, including cell transplantation, gene therapy and endogenous tissue repair. At the heart of this young field is the importance of translating laboratory-based studies to patient benefit. Thus, students will gain knowledge of the underpinning discovery science, and clinical and commercial applications. Moreover, to foster translation we will bring together researchers in different disciplines, so that the students appreciate the creative possibilities of working at the interface between different fields. Supervisors are drawn from across King’s College London, spanning clinical, nonclinical, early, mid-career and senior researchers. The first year comprises three rotations, combined with taught courses and master classes, leading to the award of an MRes. This is followed by three years of focused research. Partner organisations and secondments provide additional training opportunities. From the outset, the programme emphasizes growing as a scientist, exploring post-PhD opportunities, and the scientist in society. Students and their supervisors are seen as partners in a journey, with a special focus on fostering mutual respect and understanding.

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Researchers

Francesca M Spagnoli (EPMC Awardee)Steven Sacks (EPMC Awardee)

Related Research

Grants with similar aims, by meaning.

MRes in Tissue Engineering for Regenerative Medicine
EPSRC Centre for Doctoral Training in Tissue Engineering and Regenerative Medicine; Innovation in Medical and Biological Engineering
MRes Tissue Engineering Regenerative Medicine
EPSRC and MRC Centre for Doctoral Training in Regenerative Medicine
Application for Centre for Regenerative Medicine

Original classification

PhD Programme in Science (Basic)

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