Completed Infection & Immunity Public Health & Healthcare

Asian Clinical Trial Network

In plain English

AI plain-English summary

A new clinical trial network based in Singapore will coordinate drug-resistance research across Southeast Asia, replacing the current patchwork of one-off studies with a permanent infrastructure. Drug-resistant infections now kill more people than HIV or malaria, and Asia bears the heaviest burden. The problem is that most clinical trials in low- and middle-income countries are funded individually, forcing each project to build its own research teams, labs, and supply chains from scratch. This wastes money, slows down results, and makes it nearly impossible to compare findings across different countries or treatments. If the network succeeds, it will transform how new antibiotics and treatment protocols are tested in the region. Instead of starting from zero with every study, researchers will share standardised procedures, trained staff, and data systems. This could cut the time it takes to get a new drug from lab bench to hospital bedside, and give doctors in Asia the region-specific evidence they currently lack for treating common resistant infections. The network is a pilot. If it works, the model could be expanded to other regions facing the same crisis.

View original technical description
Drug-resistant infections (DRIs) have recently been recognised as a major challenge by the G20 and the UN General Assembly, with a disproportionate impact on the people of Asia. Potential solutions will require multidisciplinary and multi-country collaboration in order to successfully address in terms of innovative discoveries, implementation of policies and roll-out and evaluation of the best evidence based clinical practices. The current model of clinical research in low and middle-income countries (LMICs) is to fund individual clinical trials on an ad-hoc basis, with each trial requiring significant investment in research infrastructure and skills development in addition to the trial-specific costs. This model is inefficient scientifically, developmentally, and financially. In response to the challenge of AMR, Wellcome plans to set up a pilot clinical trial network (CTN) in SEA. The CTN will significantly increase the quality and efficiency of clinical trials in the region, resulting in an improved understanding of DRI, improved treatment of those infections and an increase in the supply of new drugs to fight AMR. The support hub for this clinical trial network will be based in Singapore.

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Researchers

Li Yang Hsu (EPMC Awardee)

Related Research

Grants with similar aims, by meaning.

A Clinically Oriented Antimicrobial Resistance Surveillance Network (ACORN)
Phase 2 Clinical Trial of New Antimicrobial for AMR
Promoting community engagement for clinical trials in Asia
Assessing the situation of AMR of bacteria in Vietnam, determining genomic characteristics and associated factors of common AMR-bacteria in Vietnam
Stimulating systemic regional uptake of principles of good RCTs in Low and Middle Income Countries

Original classification

Discretionary award – DRI

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