Associated organisationsDefault Community Account · IND Janice Caoili 5655 · Kwame Nkrumah University of Science and Technology · Fundação Oswaldo Cruz · University of OxfordEurope PMC affiliations are not treated as award recipients or mapped locations.
Funding£6.0M
PeriodJun 2024 — May 2029
In plain English
AI plain-English summary
A global network of clinical researchers is overhauling how the world prepares for the next outbreak—before the next virus arrives. The International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) was created to prevent illness and deaths from infectious diseases that could spark epidemics or pandemics. Its core problem: clinical research during outbreaks is often slow, fragmented, and poorly coordinated, especially in the places that need it most. Without a ready system, critical questions about patient care go unanswered while the crisis unfolds. ISARIC’s new work programme will strengthen the global clinical research ecosystem so that when a threat emerges, studies can start immediately. It will focus on acute respiratory infections, henipavirus disease, filovirus disease, and dengue, while also improving data sciences, clinical trial designs, and research management. The centre of gravity will be low- and middle-income countries, where local research leaders will be empowered to lead responses. If successful, this project will mean that future outbreaks are met with faster, more reliable evidence on how to treat patients—saving lives not through a single discovery, but through a system that works when it is needed most.
View original technical description
The International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) is a global federation of clinical research networks established in 2011. The purpose of ISARIC is to prevent illness and deaths from outbreak- prone infectious diseases. This is achieved by conducting clinical research to improve patients’ care and facilitating a globally coordinated and agile research response to infectious disease threats. ISARIC’s work programme for 2024-2029 is organised into 3 complementary platforms: clinical research, interoperability and acceleration, and capacity sharing and quality improvement. Ongoing clinical research will focus on acute respiratory infections, henipavirus disease, filovirus disease, and dengue. Through these clinical research programmes, a series of innovations will be pursued in data sciences, clinical trial designs, and research management. This ambitious work programme will generate clinically meaningful research evidence on the diseases of initial focus, whilst substantially improving clinical research readiness for emerging infectious disease threats through increased collaboration, improved interoperability, enhanced agility, and strengthened capabilities. The centre of gravity of the work will be low- and middle-income countries, and the capacity sharing and quality improvement platform will seek to empower local research leaders. Changes to ISARIC’s governance will support ISARIC’s goal to devolve responsibilities to ISARIC Hubs and enhance stakeholder engagement.
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