Active Brain & Nervous System

Out of the dark, how daytime light influences sleep and supports circadian rhythms

In plain English

AI plain-English summary

Daytime light makes the four-striped grass mouse *Rhabdomys pumilio* sleep better and strengthens its internal body clock—and researchers are now using this unusual rodent to uncover why bright days benefit human health. Most people experience disrupted sleep or circadian rhythms at some point, which can harm mental and physical health. Light is the main controller of these systems, and bright days help keep our internal clocks robust and less vulnerable to disruptive light at night. But the underlying mechanisms remain unclear because standard lab mice are nocturnal and avoid light, making them poor models for humans. This project fills that gap by studying *Rhabdomys*, a day-active rodent that naturally seeks light and shows the same therapeutic benefits from bright days that humans do. If successful, this fundamental research will reveal how daytime light alters sleep and circadian rhythms from the molecular to the behavioural level, and identify the specific cells and circuits involved. The findings could inform new treatments for attention disorders, sleep problems, and circadian disruption, as well as guide architectural design of lighting in homes, hospitals, and workplaces. Because this is curiosity-driven fundamental science, immediate applications are not guaranteed—but similar work on circadian biology has already transformed understanding of shift work, jet lag, and seasonal affective disorder, pointing to future practical uses from a deeper grasp of how light shapes our daily biology.

View original technical description
Sleep and circadian disruption is widespread, impacts health and blights lives. Light is the key regulator of sleep and circadian systems, and, in humans, bright days can enhance circadian amplitude, maintain wakefulness and reduce sensitivity to disruptive nighttime light. Elucidating underlying principles and mechanisms for these beneficial effects would provide the theoretical framework to understand relationships between light and health and reveal new targets for disorders of attention, sleep and circadian rhythmicity. Unfortunately, common laboratory rodents cannot model the human experience of light being nocturnal and photophobic. We’ve therefore established foundational knowledge and advanced experimental approaches for a light-seeking day-active murid (Rhabdomys pumilio). Rhabdomys recapitulate therapeutic benefits of daytime light providing a unique opportunity to establish: 1) the impact of brighter days on circadian rhythms and sleep from molecules to behaviour; 2) the underpinning cell and circuit mechanisms; and 3) the pre-clinical insight to inform interventions. In doing-so, we will extend understanding of circadian and sleep physiology to account for fundamental aspects of human biology; inform therapeutic and architectural application of light; identify new approaches to modulate influential aspects of physiological/behavioural state; and develop tools and resources to support adoption of Rhabdomys as a more translatable model in discovery research.

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Researchers

Beatriz Bano Otalora (EPMC Awardee)Robert Lucas (EPMC Awardee)Timothy Brown (EPMC Awardee)

Related Research

Grants with similar aims, by meaning.

The impact of daytime light exposure on diurnal and circadian rhythms in the diurnal rodent Rhabdomys pumillio
Chronotype and circadian reafference: the impact of free will on the mammalian circadian clock
Understanding the contribution of early-life light environment to circadian clock function in adulthood
Mechanisms of circadian disruption by the modern light environment
Consequences of Artificial Light Exposure for Healthy Physiology

Original classification

Discovery Award

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