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Development of an ultra-rapid, point-of care diagnostic system for Chlamydia and gonorrhoea

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A disposable cartridge and a low-cost reader will diagnose Chlamydia and gonorrhoea from a patient sample in minutes, without any lab equipment or trained staff. Current tests for these sexually transmitted infections require sending swabs to a central laboratory, which takes days and loses many patients to follow-up. This project builds a DNA-based diagnostic system that processes the sample automatically from start to finish, with all reagents stored inside the disposable cartridge. The reader uses a novel electrochemical detection method to keep the instrument small, cheap, and virtually maintenance-free. On-board quality controls ensure accuracy, and the system’s high multiplex capability allows future expansion to other infections. If successful, the pre-production prototype—tested in real clinical settings with the Health Protection Agency—could shift diagnosis from central labs to GP surgeries, sexual health clinics, or even pharmacies. Faster results would let patients receive treatment immediately, cutting transmission chains and reducing the burden of untreated infections. The collaboration between Atlas (electrochemical assay design) and Randox Laboratories (engineering and market reach) aims to turn fundamental science into a practical tool that quietly improves public health infrastructure.

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This project is to develop a system for ultra-rapid and highly sensitive, DNA-based Point-Of-Care tests for Chlamydia and gonorrhoea. The system will use a disposable cartridge for testing a patient sample which will be processed using a low cost reader instrument. The system will have innovative features ensuring ease of use & accuracy which include: • automated end-to-end processing of samples with no user intervention • all reagents stored on cartridge making the reader simple to use and virtually maintenance-free • a novel & sensitive electrochemical detection system allowing the reader to be small and low cost • on-board quality controls, and high multiplex capability for future menu expansion The core technology comes from research carried out at Atlas and the project combines the expertise in electrochemical assay design, reagent formulation and fluidic design at Atlas with market understanding and engineering capability at Randox Laboratories, a leading UK diagnostics company. The Health Protection Agency will provide clinical expertise, and coordinate the clinical evaluation. The project will deliver a pre-production prototype of the system fully tested in relevant clinical settings.

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Related Research

Grants with similar aims, by meaning.

A rapid cost-effective and highly sensitive point of care platform for detection of Chlamydia and Gonorrhoea
Development of a rapid multiplex Lab on a Chip system for detection of 10 STI pathogens using Biochip Array Technology
Fast Point-of-Care Testing for Sexually Transmitted Diseases: Expanding the scope of testing
Development of a rapid multiplex Lab on a Chip system for detection of 10 STI pahtogens using Biochip Array Technology
Development of an Instrument-Free Molecular Diagnostic Test for Chlamydia and Gonorrhoea

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