Completed Heart, Stroke & Blood Cells, Biochemistry & Physiology

Acute Vascular Imaging Centre for Oxford (OxAVIC)

In plain English

AI plain-English summary

A new clinical research centre at the John Radcliffe Hospital will scan stroke and heart attack patients with advanced imaging equipment while they are still in the emergency department, rather than moving them to a separate research facility. Researchers do not fully understand why many patients still suffer lasting damage despite clot-busting drugs and angioplasty. Current research facilities are either unavailable during acute events or cannot safely accommodate critically ill patients. This centre solves that problem by embedding state-of-the-art scanners directly within the accident and emergency unit, allowing scientists to watch what happens in the brain and heart in real time as treatments are administered. If the centre succeeds, it could reveal why some patients fail to recover and point toward better drug regimens, improved clot-removal techniques, or entirely new treatment strategies. The work is applied clinical research with a clear goal: reduce death and disability from strokes and heart attacks, which together remain leading causes of death and long-term disability in the UK. The centre will also serve as a hub for Oxford University researchers from cardiology, neurology, radiology, and biomedical engineering to collaborate on these common conditions.

View original technical description
This application is for a clinical research centre (CRC) that will allow the close monitoring of patients as they receive treatments for acute vascular events, in a safe environment at the heart of the John Radcliffe Hospital. Crucially the CRC will focus on investigating patients at the time they are having strokes and heart attacks. It will take advantage of medical advances, particularly in imaging, to improve our understanding of these illnesses and explore new avenues to improve care and outcomes for patients. The novel aspect of this proposal is to place this state-of-the-art imaging at the core of where acute clinical care is provided, namely, the Accident and Emergency Department. Researchers still have a great many questions to answer about why patients do not recover despite current treatment strategies, such as angioplasties and the use of clot-busting drugs. Traditionally, such research facilities are either unavailable or do not provide safe environments for patients at the time of the stroke or heart attack. The CRC will provide a focus to bring together the research expertise from many complimentary areas within Oxford University, to understand how we can develop new treatments or improve on existing treatment for these common conditions.

View the original record at the funder ↗

Researchers

Alastair Buchan (Principal Investigator)

Related Research

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Original classification

Research Grant

Plain English summaries and category classifications on this site are generated by AI and may not perfectly reflect the original research.