Active Genetics & Molecular Biology Cells, Biochemistry & Physiology

MultiScale phenomena in Radiation Damage

Summary

Original abstract (not yet simplified)

The MS-RADAM DN will deliver a state-of-the-art research programme that will pioneer a new approach to reveal key nano- and larger-scale radiation biodamage phenomena based on multiscale modelling (MM) and its thorough validation using advanced experimental techniques and technological applications. In particular, the MS-RADAM research programme will focus on obtaining an advanced understanding of Radiation Damage (RADAM) phenomena induced by...

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The MS-RADAM DN will deliver a state-of-the-art research programme that will pioneer a new approach to reveal key nano- and larger-scale radiation biodamage phenomena based on multiscale modelling (MM) and its thorough validation using advanced experimental techniques and technological applications. In particular, the MS-RADAM research programme will focus on obtaining an advanced understanding of Radiation Damage (RADAM) phenomena induced by ion irradiation in biomolecular and biological systems relevant to the application of this knowledge in particle therapy and many other relevant areas of research and technology.The unique feature of the MS-RADAM research programme is the MM description and measurement of key processes and phenomena occurring on different temporal and spatial scales during ion-beam irradiation incorporating: (i) propagation of charged particles in biological media, (ii) radiation-induced fast quantum processes within biomolecular environments, (iii) characterisation of the time and spatial evolution of track structures and localised energy deposition, (iv) slower nanoscale post-irradiation relaxation, chemical and thermalisation processes occurring in the irradiated biological media, (v) evaluation of biodamage accounting for specific radiobiological effects. To initiate such a programme and to provide industry, radiotherapy research community and many other related communities with a cohort of skilled researchers, MS-RADAM DN will train 14 Doctoral Candidates (DCs) in the methodology and skills needed for this emerging area of research and technology.MS-RADAM DN contains leading academic and industrial partners with the necessary experience to provide the international, interdisciplinary and intersectoral training needed for the MS-RADAM research programme, whist also providing the DCs a unique opportunity to gain comprehensive training in the complementary and entrepreneurial skills for their further career development.

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