Completed Pregnancy, Children & Inherited Conditions Mathematics & Statistics

Evaluating and enhancing the scale-up and population impact of concurrent HIV/AIDS prevention and treatment services in a well-characterised previously declining epidemic in sub-Saharan Africa.

In plain English

AI plain-English summary

In Zimbabwe, researchers are tracking 12,000 people over time to measure whether the country’s expanded HIV prevention and treatment services are actually cutting new infections and deaths. This matters because Zimbabwe’s HIV epidemic, once declining, could stall or reverse if services are not reaching the right people effectively. The research fills a gap: most studies measure clinic-level outcomes, not population-level impact. By combining long-term health data with mathematical models, the team can isolate which specific services—such as antiretroviral therapy or condom distribution—are driving any observed changes. If successful, the work will show policymakers exactly where to strengthen service delivery, from improving drug supply chains to addressing why some people avoid clinics. The findings could reshape how other sub-Saharan countries allocate limited resources for HIV programmes. This is applied public health research: its direct goal is to save lives by making existing tools work better at scale, not to discover new biological mechanisms.

View original technical description
In the proposed research, we aim to measure and evaluate the impact of scaled-up evidence-based HIV/AIDS prevention and treatment services on HIV infection and AIDS mortality at the population level in Zimbabwe. This will be done by: (i) continuing to monitor trends in HIV prevalence, HIV incidence and mortality and trends in utilization of prevention and treatment services in a large-scale (n=c12,000) general population cohort in eastern Zimbabwe; (ii) measuring associations between service uti lization and risks of infection and death at the individual level; and (iii) using mathematical models to isolate the likely contributions of increased availability and uptake of services to trends in the epidemic observed at the population level. Qualitative research and mathematical models will be used to identify ways in which the impact on the HIV epidemic could be enhanced by addressing factors affecting the demand for and supply of services.

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Researchers

Gregson (EPMC Awardee)

Related Research

Grants with similar aims, by meaning.

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Improving HIV testing and care for adolescents in Zimbabwe: A targeted, community-based approach
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An epidemic in retreat? Establishing the population impact of combination prevention strategies in a resource-poor, hyper-endemic rural African population

Original classification

Programme Grant

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