Completed Psychology & Behaviour Brain & Nervous System

Predicting language outcome and recovery after stroke.

In plain English

AI plain-English summary

A stroke patient's ability to speak or understand language in the months after their brain injury could be predicted by a new web-based tool, rather than left to guesswork. Around a third of stroke survivors experience aphasia—loss of language abilities—yet doctors currently have no reliable way to forecast who will recover and how quickly. This project tackles that gap by combining three parallel approaches: identifying which brain lesions and patient characteristics lead to long-term communication problems; mapping the brain networks that compensate for damaged language areas using functional imaging; and building a probabilistic prediction tool from that data. If successful, the research will produce an easy-to-use online system that gives patients, carers, and clinicians a personalised recovery timeline based on how similar cases have progressed. This could transform post-stroke care from vague reassurance to concrete planning—helping families prepare for care needs, therapists target their efforts, and patients set realistic expectations. The tool would not replace clinical judgment but would add a data-driven layer to decisions about speech therapy intensity and discharge timing. The work is applied from the outset, designed specifically for clinical deployment rather than as a fundamental science investigation.

View original technical description
The main goal is to provide proof of principle for a clinically useful tool that will predict recovery of language abilities after stroke. There are three separate but interacting lines of research, to be conducted in parallel: (A) Using structural neuroimaging and behavioural assessments, we will identify lesion and non-lesion factors that are most likely, and least likely, to cause long term communication difficulties. The influence of the identified factors will be tracked over months and years following the stroke to understand how recovery unfolds over time. (B) Using functional neuroimaging and dynamic causal modelling, we will map the brain areas that are activated when the patient is speaking or comprehending speech. This will provide a mechanistic understanding of the language pathways that are able to support recovery after damage to the normal system. (C) We will develop an easy-to-use web-based system that will provide patients, their carers and clinicians with t he likely time course of recovery on the basis of probabilistic summaries of other patients in our database who have corresponding brain damage according to the carefully constrained criteria developed in (A).

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Researchers

Catherine Price (EPMC Awardee)

Related Research

Grants with similar aims, by meaning.

Predicting Language Outcome and Recovery After Stroke
Towards a new neurological model of language that explains outcome after stroke.
Explaining Language Outcome and Recovery After Stroke (ELORAS)
Using neuroimaging measures to predict and to understand speech recovery patterns in bilingual stroke patients.
How the human brain supports language in different ways

Original classification

Principal Research Fellowship (New)

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