Wellcome Trust Centre for Molecular Parasitology.
In plain English
AI plain-English summaryParasitic infections in the tropics cause devastating diseases, and a Glasgow-based centre is using a multidisciplinary approach—combining genomics, computer modelling, and advanced imaging—to find new drug targets and vaccine candidates. The centre focuses on two major groups of parasites: apicomplexans (which cause malaria and toxoplasmosis) and trypanosomatids (which cause sleeping sickness and Chagas disease). These parasites have complex life cycles and evade the immune system, making them difficult to treat. The centre’s strength lies in its integration of “polyomics”—the simultaneous analysis of genes, proteins, and metabolites—with computational modelling to predict how parasites behave and how drugs might disrupt them. If successful, this work could lead to the discovery of new drug targets and vaccine candidates, directly addressing the lack of effective treatments for diseases that affect hundreds of millions of people. The centre also trains the next generation of researchers and builds partnerships with institutions in disease-endemic regions, ensuring that findings translate into real-world impact. While much of this research is fundamental science—unravelling the molecular biology of parasites—it lays the groundwork for practical interventions that could save lives.
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