Active Infection & Immunity Plants, Animals & Ecology

One Health Models of Disease: Science, Ethics and Society

In plain English

AI plain-English summary

Genome editing and animal bioscience are creating powerful new ways to model human diseases in animals, but the scientists who build these models rarely get training in the ethical and social questions they raise. This PhD programme tackles a gap in graduate education. Researchers can now design “One Health” models—animals that mimic neurodegenerative, cardiovascular, developmental, and infectious diseases affecting both humans and animals. These models could transform how scientists understand disease mechanisms and test therapies. But no existing programme combines hands-on training in these cutting-edge techniques with rigorous instruction in bioethics and social science. Without that training, scientists may develop powerful tools without fully grasping their societal implications. If successful, the programme will produce a new generation of researchers who can both create advanced disease models and think critically about their ethical use. Students will rotate through labs, complete internships with academic, industrial, policy, and stakeholder organisations, and be supervised jointly by life scientists and social scientists. The result could be a more responsible, publicly accountable approach to animal-based disease research—one that anticipates ethical dilemmas rather than reacting to them.

View original technical description
Technological advances in genome editing and animal bioscience have potential for huge societal impact, and are opening up opportunities for the design of new ‘One Health’ models of neurodegenerative, cardiovascular, developmental, and infectious diseases of humans and animals. Such models can transform our approach to understanding pathogenesis, facilitating the development of therapies or preventive measures. However, there is little or no opportunity for graduate student training in relevant state-of-the-art techniques at world-class, purpose-built facilities by leading scientific innovators at the intersection of human and veterinary medicine. Moreover, scientists require training in bioethics and social science to allow them to appreciate the ethical and societal implications of these powerful new approaches. To address this need, we propose a PhD programme in “One Health Models of Disease: Science, Ethics and Society”. This innovative, and versatile programme will combine core training in relevant experimental techniques, bioethics and social sciences relating to One Health, rotation research projects, and internships with academic, industrial, policy and stakeholder organisations, alongside the main PhD project. Students will be supervised by world-leading life scientists addressing important diseases of humans and animals, and social scientists and bioethicists conducting cutting-edge research into the social and ethical dimensions of 21st century science.

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Researchers

Martyn Pickersgill (EPMC Awardee)Ross Fitzgerald (EPMC Awardee)

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Original classification

PhD Programme in Science (Basic)

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