Completed Plants, Animals & Ecology Mathematics & Statistics

Informing strategies for malaria eradication: a combined epidemiological and economics approach

In plain English

AI plain-English summary

Malaria cases have fallen sharply over the past decade, but that decline has now stalled. This project asks how to get eradication back on track by combining mathematical models of malaria transmission with economic analysis of real-world decision-making. The core problem is that what makes sense for one country—say, focusing on reducing deaths right now—may undermine the global goal of wiping out the parasite everywhere. Researchers will model these trade-offs explicitly: whether to prioritise high-burden nations or those already close to elimination, how short-term health needs conflict with long-term eradication, and what level of international cooperation is actually required. If successful, the work will produce concrete, evidence-based strategy options for funders and policymakers. Rather than relying on aspirational targets, national health ministries and global bodies such as the WHO and the Global Fund could use these findings to allocate limited resources more effectively—deciding, for example, when to invest in bed nets versus surveillance systems, or how to design financial incentives that encourage countries to act in a coordinated way. The research does not develop a new drug or vaccine; it addresses the political and economic machinery that determines whether those tools ever get used at scale.

View original technical description
The last decade has witnessed substantial declines in the global burden of malaria; however, in recent years progress has stalled. We aim to combine a mathematical modelling framework with economic analyses to gain insight into the optimal global, regional and country strategies to achieve the ultimate aim of malaria eradication. Specifically: - What is the optimal strategy to achieve malaria eradication? Should resources initially focus on high burden countries, elimination countries or a balance between these? How does this change as burden and transmission decline? How do competing aims in the short-term (e.g. the need to reduce morbidity and mortality) hamper achieving longer-term eradication aims? - What is the trade-off between country priorities and regional and global strategies? How do competing national priorities determine regional and global success? What degree of international cooperation is needed and at what scale? What are the economic benefits and costs of co-operation to countries? - How are strategies influenced by the wider political economy? How do competing priorities influencing national decision makers impact wider eradication efforts? How does weak governance and political constraints in national and international decision-making reduce the effectiveness of strategies?

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Researchers

Azra Ghani (EPMC Awardee)Katharina Hauck (EPMC Awardee)

Related Research

Grants with similar aims, by meaning.

Developing model applications to support national malaria elimination strategies
Economic evaluation of strategies for disease eradication
Methodological development in whole-economy modelling: P. falciparum malaria control in Africa
Synthesising data from multiple spatial scales and levels of detail to improve malaria transmission model predictions
Improving the efficacy of malaria prevention in an insecticide resistant Africa

Original classification

Investigator Award in Science

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