Completed Infection & Immunity Heart, Stroke & Blood

A Rapid and Substantial Increase in Supplies of an Effective, Safe and Affordable Antivenom to sub-Saharan Africa

In plain English

AI plain-English summary

A factory in the UK will start producing a new version of an antivenom that was previously taken off the market, aiming to get it to African hospitals within a few years. This matters because snakebites kill tens of thousands of people in sub-Saharan Africa each year, and the most effective antivenom for the region, Fav-Afrique, stopped being made. The manufacturer, MicroPharm, is working with the Liverpool School of Tropical Medicine to restart production using plasma from horses immunised against the four most dangerous snake groups: saw-scaled vipers, puff adders, cobras, and mambas. The project modernises the manufacturing process to make more antivenom at a lower cost. If the project succeeds, hospitals across sub-Saharan Africa will have a reliable supply of a safe, effective treatment for the snakes that cause the most deaths and disabilities. This is not fundamental science—it is a direct response to the World Health Organization’s goal of reducing snakebite mortality and morbidity. The impact will be felt in emergency rooms and rural clinics, where a shortage of the right antivenom currently means patients either go untreated or receive ineffective substitutes.

View original technical description
The project will be directed by MicroPharm and will include contributions by scientists at the Liverpool School of Tropical Medicine. It is in direct response to the WHO's stated aim of reducing the mortality and morbidity of snake envenoming. The aim of the project is to re-establish supplies of Fav-Afrique in its current format as an equine F(ab’)2 based antivenom suitable for the treatment of Category 1 venomous African snakes. Sanofi-Pasteur will continue to supply large pools of plasma from horses immunised with venoms from Echis, Bitis, Naja or Dendroaspis species respectively. The manufacturing procedures will be modernised and simplified to increase yield and decrease cost. Initial supplies will be available for clinical use in Africa by 2023.

View the original record at the funder ↗

Researchers

John Landon (EPMC Awardee)Matthew Aldridge (EPMC Awardee)Rossen Donev (EPMC Awardee)

Related Research

Grants with similar aims, by meaning.

Novel immuno-proteomic strategies to develop a polyspecific, non-cold chain liquid snake antivenom with unparalleled sub-Saharan African efficacy
Progressing existing snake venom toxin-specific antibodies into humanised, thermostable monoclonal therapies for preclinical manufacture and clinical trials in Africa and India
Multi-centre Antivenom Trial in Africa
Recombinant snakebite antivenom for sub-Saharan Africa
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments

Original classification

Discretionary Award - Snakebite

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