Associated organisationsCabi · Earlham Institute · European Bioinformatics Institute · Kew Royal Botanic Gardens · Marine Biological Association · Natural History Museum · Royal Botanic Garden Edinburgh · University of Cambridge · University of Edinburgh · University of OxfordEurope PMC affiliations are not treated as award recipients or mapped locations.
Funding£2.5M
PeriodNov 2022 — Nov 2024
In plain English
AI plain-English summary
The Darwin Tree of Life project is sequencing the genomes of all 70,000 known species of plants, animals, and fungi across Britain and Ireland. After three years of building the necessary infrastructure, the consortium has collected around 5,000 species and released roughly 2,000 complete genomes. Now, with two years of additional funding, they will scale up collection and data delivery to demonstrate that sequencing an entire nation’s biodiversity is feasible. This matters because we lack a complete genetic inventory of life on Earth. Without it, we cannot fully understand how species evolve, how ecosystems respond to climate change, or what genetic tools nature has already invented. The project fills a fundamental gap: we know species exist, but we do not know the genetic blueprints that make them tick. If successful, the project will produce an open-access catalogue of eukaryotic gene toolkits. This is primarily fundamental science—it will transform evolutionary biology and ecology. But the data could also enable practical applications: monitoring ecosystem health under environmental stress, identifying genetic resources for biotechnology, or informing conservation priorities. Similar large-scale genomics projects have already revolutionised medicine; this one could do the same for biodiversity science.
View original technical description
Life has evolved from a single origin to generate over 1.8 million eukaryotic species. Sequencing the genomes of all species will provide an inventory of life, transform understanding of evolution, catalogue eukaryotic gene toolkits for biology and biotechnology, and enable monitoring of ecosystems under increasing stress. The Darwin Tree of Life (DToL) project was founded to collaboratively sequence all species (~70,000 described) in Britain and Ireland to the highest quality standards to demonstrate the feasibility of large scale biodiversity genomics. We believe that these data will transform biology forever. Our consortium of biodiversity, sequencing and analytic partners has through the last three years - and despite the covid pandemic - built systems for collection, identification, extraction, sequencing, assembly and annotation of genomes at scale, with all data released openly. We will have collected ~5000 species and released ~2000 genomes by the end of the first phase of DToL this year. With the core competencies in place, we are now seeking two years of funding to support our biodiversity and analytic partners in extending their collection and data delivery activities. During these two years we will broaden our funding base to be able to complete our goals by 2030.
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