A Discovery Research Tissue Scale Biology Platform (TSBP)

Importance of Barrier and Potential to Overcome it: Biomedical research is performed at multiple scales, ranging from the molecular up to populations. To capitalize on discoveries made at one particular scale, we must work smoothly across scales, for example to translate a molecular discovery into a new treatment. Particularly for research focused on human biology and disease, the tissue or organ scale is a major bottleneck. Stem cells build, maintain, and repair our tissues. The Cambridge Stem Cell Institute represents the leading centre for stem cell research in Europe, and is therefore in prime position to tackle the Tissue Scale bottleneck. We have identified organs in a dish, lineage analysis, tissue scale imaging/molecular profiling and computational modelling as specific barriers which we will break down to empower a new era of Tissue Scale Biology research. Breadth of Impact: Underpinned by a new network of technologists from local and international centres of excellence, our innovations will enable a new wave of discovery and translational science relevant for most areas of biomedical research. Research Environment: Personal development and positive culture are integral to this application, bolstered by over £2M Institutional Support, including new degree apprenticeships with Anglia Ruskin University to widen participation.