Active Infection & Immunity

Interventions to improve antibiotic stewardship

In plain English

AI plain-English summary

Drug-resistant infections are spreading faster than new antibiotics are reaching patients, and the International Centre for Antimicrobial Resistance Solutions (ICARS) is working directly with low- and middle-income countries to stop that trend. This matters because antimicrobial resistance already kills hundreds of thousands of people each year, and the pipeline for new drugs is thin. Many countries have national action plans to tackle AMR but lack the on-the-ground capacity to turn those plans into real changes in how antibiotics are prescribed on farms and in clinics. ICARS fills that gap by designing and testing practical interventions—such as better diagnostic tools or prescribing guidelines—and then helping governments implement what works. If this partnership succeeds, ICARS will expand its reach from its current projects across multiple countries and continents to a more sustained regional presence. That could mean fewer unnecessary antibiotic prescriptions in livestock and humans, slower emergence of resistant bacteria, and stronger health systems that can keep common infections treatable. The work is applied and implementation-focused: it aims to change behaviour and policy now, not to discover new molecules.

View original technical description
Since its inception in 2018, the International Centre for Antimicrobial Resistance Solutions (ICARS) has become a key partner of Low- and Middle- Income Countries (LMICs) facilitating their efforts to mitigate antimicrobial resistance (AMR) and implement their AMR National Action Plans by working at both political and technical levels. ICARS kick-started the development of over 30 projects across the One Health spectrum, spanning 16 countries and four continents and has proven itself as an agile and effective[SE1] organisation with a novel value proposition based on intervention and implementation research. To maximize its impact, ICARS has set an ambitious future agenda with its 2022-2026 strategy. The strategic partnership with Wellcome will enable ICARS to expand beyond its current capacity, mature as an organisation and respond to the growing demand from LMICs. Specifically, the partnership will 1) strengthen ICARS’ innovative top-down, bottom-up model and ways of working, 2) facilitate sustainable regional impact by piloting ICARS’ regional presence and 3) harness partnerships for sustainable global impact. The ICARS-Wellcome partnership spanning five years will give effect to the common vision of ICARS and Wellcome of a world where drug-resistant infections no longer pose a threat to the health and wellbeing of humans, animals and the environment.

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Researchers

Ghada Zoubiane (EPMC Awardee)Helle Krarup (EPMC Awardee)Mirfin Mpundu (EPMC Awardee)Robert Skov (EPMC Awardee)Sabiha Essack (EPMC Awardee)

Related Research

Grants with similar aims, by meaning.

Antibiotic stewardship in agricultural communities in Africa and Asia: A unified One Health strategy to optimise antibiotic use in animals and humans
Jpiamr- antimicrobial transmission interventions
Lowering AntiMicrobial Prescribing (LAMP) campaign (linked to Implementation Lab, funded through West Yorkshire R&D)
Advanced Multidisciplinary Research for Antimicrobial Resistance
CATCR: Central Africa Training Platform for Clinical Research on infectious diseases

Original classification

Discretionary Award

Plain English summaries and category classifications on this site are generated by AI and may not perfectly reflect the original research.