MOST-Nexus: Transforming Global Youth Mental Health with Hyper-Personalised, Adaptive Scalable Digital Care

Digital mental health interventions (DMHIs) offer a promising solution to the youth mental health (YMH) crisis, but poor engagement limits real-world scalability, sustainability, service integration, and impact. MOST (Moderated Online Social Therapy), a multi-award-winning platform co-designed with young people and services, is a proven effective and scalable solution. Now integrated into 400+ YMH services, it combines evidence-based therapy, peer support, and remote clinical care. To scale MOST globally, we will tackle four key challenges:1. Delivering scalable, data-driven personalisation.2. Balancing human support and cost-effectiveness3. Bridging the research-to- real-world gap. 4. Developing innovative, sustainable models. Driven by world- class research, industry, and lived experience (LE) experts, we will leverage our unique infrastructure to create, evaluate, and scale MOST-Nexus, the world’s first hyper-personalised, adaptive digital platform for YMH. Phase 1 will create MOST-Nexus, integrating AI-driven hyper-personalisation (Work Package (WP)1) and optimising human support (WP2) for enhanced engagement, cost-effectiveness and real-world scalability.Phase 2 will adapt and evaluate MOST-Nexus internationally (WP3; Netherlands, Germany, Spain), and build a sustainable model for global expansion and equity (WP4). MOST-Nexus will transform YMH outcomes globally, delivering a scalable, cost-effective solution that integrates with overstretched services and operates independently in low-resource settings, driving the next generation of DMHIs.