Active Public Health & Healthcare Mental Health

System: A Systems-Level View of Health

In plain English

AI plain-English summary

Health data is currently stored as isolated facts—a blood pressure reading here, a postcode there—with no links between them, even though 80% of health outcomes are shaped by social and environmental factors outside the clinic. This matters because the current approach treats health as a collection of independent pieces: organs, diseases, genes. The relationships between those pieces—the cause-and-effect connections that actually determine whether someone gets sick or stays well—are invisible. Without seeing those links, doctors, researchers, and policymakers cannot understand a patient or population as a whole system. System is building an open, living model of health—a large-scale graph that automatically links millions of determinants, interventions, and outcomes by mining evidence from scientific literature, expert databases, and real-world data. The graph updates itself as new evidence emerges and is exposed through APIs for researchers and developers. If successful, this could transform how health data is organised and used. Instead of siloed records, researchers could trace how a change in housing policy might affect diabetes rates, or how air quality interacts with a genetic predisposition. The infrastructure would quietly underpin better clinical decisions, more targeted public health interventions, and more realistic policy modelling—without requiring any change in how patients experience a doctor’s visit.

View original technical description
Health is a complex system made up of interconnected factors. Yet today, health is viewed in silos: organs, diseases, genes, etc. 80% of health outcomes result from factors outside the clinical context, like social and environmental determinants. Yet these factors are rarely considered, let alone linked at the patient level to traditional clinical biomarkers. Health data is currently modeled as a set of discrete factors, as if each were independent. The critical relationships between the data points — the basis of cause and effect — are invisible. Simply put, we don’t organize health data the way we actually understand health, i.e. as a system, compromising care, research, and policy.At System, we are building an open, living systems model of the world, starting with health — and with it the critical knowledge and data infrastructure to finally see a patient or population's health as a whole. At the core is the System Graph, a large-scale graph that links millions of determinants, interventions, and outcomes based on automated statistical meta- analysis of evidence extracted from verified sources like scientific literature, expert-curated databases, and real-world data. The graph is updated and recomputed regularly as new evidence emerges and exposed through APIs to researchers and developers.

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Researchers

Adam Bly (EPMC Awardee)

Related Research

Grants with similar aims, by meaning.

Health Systems in History: ideas, comparisons, policies.
Systems Science Research in Public Health (SysSci)
Complexity in Health
Outcomes Based Healthcare: Passively Predicting Health Outcomes
Healthy Urban Places: a systems approach to understanding how to harness the power of local places to improve population health and reduce inequalities (HUP-North)

Original classification

Discretionary Award

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